ID A4HME2_LEIBR Unreviewed; 705 AA.
AC A4HME2;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=LBRM_34_1120 {ECO:0000313|EMBL:CAM43329.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM43329.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM43329.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM43329.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM43329.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM43329.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR799009; CAM43329.1; -; Genomic_DNA.
DR RefSeq; XP_001568222.1; XM_001568172.1.
DR AlphaFoldDB; A4HME2; -.
DR STRING; 5660.A4HME2; -.
DR GeneID; 5419172; -.
DR KEGG; lbz:LBRM_34_1120; -.
DR VEuPathDB; TriTrypDB:LbrM.34.1120; -.
DR VEuPathDB; TriTrypDB:LBRM2903_340017300; -.
DR InParanoid; A4HME2; -.
DR OMA; MKVYPLY; -.
DR Proteomes; UP000007258; Chromosome 35.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF261; RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:CAM43329.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 40..201
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 226..404
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 705 AA; 79838 MW; AEB7B8E14EC10C48 CRC64;
MEANHSTRNH LTGRAYSSHY FTLLKIREQL PISAAKSRIQ KLVSQYQTLL LVGETGSGKT
TQVPQYILEL KPERRIACTQ PRRVAATSVS ERVAEEMDVE LGEEVGYSIR FDDKCSEKTR
LKYLTDGMLL REAMVDPLLS SYSVIVLDEA HERTVSTDIL IGTLKELLPK RPDLRVVVMS
ATLEEKRFQE YFPKAPLVHI SGRMYGVEVY YSKAPEANYV EAAIRTATQI HLYEGEGDIL
IFLTGEDEIE TTVERLQNGI RMAEHSSANC HHGPVVVLPL YSALPPSQQR KVFKTAPEGT
RKIVVATNVA ETSLTIAGVV FVVDCGFSKQ KVFNPKLRVE SLLVTPISQA SARQRCGRAG
RTKPGKCFRL YTAKSFHSAL QPNTYPEILR CNLGSIVLHM KKMGIEDLVN FDFVEPPAPE
TLMRALELLN FLGALDDDGN LTKEGSLMSE FPVDPEMASM LFHSPKFGSS EDIARISAML
SVQNPFITPS NDQRGRAMRC REQFYHPTGD HIAYLNAFNA FYEVNNQSTS WCTENYINPR
VMKQAVNIYR QLVGILRRLN LPINSTYTAQ QRHVQHEDAP AELEFANDVR RAIVKGYFTK
VALSLPTKHQ FMTLKDDVKC LLFPSTYLNR RPKFVVFNEL VLTSNTYIRT VTAVSEDWLL
ESSPSYFAQD EFEGVTKQVF DDIFRRANKE KERRSKRTRS PTGDD
//
