ID A4HMQ0_LEIBR Unreviewed; 525 AA.
AC A4HMQ0;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=ATP-grasp domain-containing protein {ECO:0000259|PROSITE:PS50975};
GN ORFNames=LBRM_34_2210 {ECO:0000313|EMBL:CAM43438.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM43438.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM43438.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM43438.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM43438.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM43438.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR799009; CAM43438.1; -; Genomic_DNA.
DR RefSeq; XP_001568330.1; XM_001568280.1.
DR AlphaFoldDB; A4HMQ0; -.
DR STRING; 5660.A4HMQ0; -.
DR GeneID; 5419281; -.
DR KEGG; lbz:LBRM_34_2210; -.
DR VEuPathDB; TriTrypDB:LbrM.34.2210; -.
DR VEuPathDB; TriTrypDB:LBRM2903_340029300; -.
DR InParanoid; A4HMQ0; -.
DR OMA; PQCWAAS; -.
DR Proteomes; UP000007258; Chromosome 35.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR PANTHER; PTHR43585:SF2; ATP-GRASP ENZYME FSQD; 1.
DR PANTHER; PTHR43585; FUMIPYRROLE BIOSYNTHESIS PROTEIN C; 1.
DR Pfam; PF13535; ATP-grasp_4; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 150..373
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
SQ SEQUENCE 525 AA; 57118 MW; C9D69A9D16B2F4A0 CRC64;
MDGKVVVFIC TSSGSRLPLY RRLRSLGLTL VLVHPCTPSP VFDGIFQYWL QHDTDDVEGV
YLALSAFLAS HRLVPDAVVS FDEYGVHQAV VLADRLNLTP VPLPDAALLQ NNLKHSFRGF
CSEHGISSPK SRPLPVEMLL PTLGEMSNLA RDADALSMAF EKTQPALTKA VSMTMEASAF
TFPIVLKPSP GAGSLLVRLC TTLDAAVAFV WHMWTTLANH PDTKHFAALT NRKLAGAVRK
GVTSPVQILV EDFIEGQEVD LDCIIEHGVV RFCSISDNFA PSLPYFAEVG GLCPSSLGYR
AQCAMRDLLD SYVRAHGARL HGVIHFEAKY DPARQRAYVI EVNCRPGSAE TSAMLQTVYR
GLNLGEALVR CALQMPIEEQ LASLFPELLA SQQEKSAAQT PWQKVTPPCL SEAELDAHIP
STTVCSAMWS LLGGPSLGFF PPQCWAASTN MYPTQAGVLV KARAPVEDVS LVSFFISAEV
GQIVTPPPKQ FCMLCWMVAK GATAEQAKDN ILRVTNAFDQ EVSAV
//
