ID A4HNL1_LEIBR Unreviewed; 324 AA.
AC A4HNL1;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 22-FEB-2023, entry version 69.
DE RecName: Full=SAP domain-containing protein {ECO:0000259|PROSITE:PS50800};
GN ORFNames=LBRM_35_0110 {ECO:0000313|EMBL:CAM43763.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM43763.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM43763.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM43763.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM43763.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM43763.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR799010; CAM43763.1; -; Genomic_DNA.
DR RefSeq; XP_001568637.1; XM_001568587.1.
DR AlphaFoldDB; A4HNL1; -.
DR GeneID; 5419606; -.
DR KEGG; lbz:LBRM_35_0110; -.
DR VEuPathDB; TriTrypDB:LbrM.35.0110; -.
DR VEuPathDB; TriTrypDB:LBRM2903_350006600; -.
DR InParanoid; A4HNL1; -.
DR OMA; KNNSIWG; -.
DR Proteomes; UP000007258; Chromosome 36.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR Pfam; PF02037; SAP; 1.
DR SMART; SM00513; SAP; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR PROSITE; PS50800; SAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 180..214
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
FT REGION 126..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..324
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 324 AA; 34994 MW; 53A8862F4B8979A9 CRC64;
MDPVKRRLVY VADESEVLLK ELSGTPPTRQ SRMTRLLVPL SPPTPSQKST HSVSPLPRPI
DTIAKVAPLA MADTALLVSY DGFLLTDGNG RFTTPRDAAQ AEKIRDALKS CRAFLKEFLD
AAQAERASTE SYSSAASSST YMEEEDSDLE DSSSNESPPP RPRAATAVKA RPPHAQPVTP
SQMTVAELKA FLRDRGLLTT GNKESLVKRV QKAQRARNSV RGAATVPACG AASRRSLQGS
HSGPNTLSSD VLMSPPPVGQ RPPQLPSPNS YTNDEKNSGL WDVLVHAGSR LFRGGARTSW
GFHSRQPEDA DDAPLSKRCR LGTE
//
