ID A4HQG6_LEIBR Unreviewed; 441 AA.
AC A4HQG6;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Putative histidine secretory acid phosphatase {ECO:0000313|EMBL:CAM44432.1};
GN ORFNames=LBRM_35_6790 {ECO:0000313|EMBL:CAM44432.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM44432.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM44432.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM44432.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM44432.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM44432.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC {ECO:0000256|ARBA:ARBA00005375}.
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DR EMBL; FR799010; CAM44432.1; -; Genomic_DNA.
DR RefSeq; XP_001569291.1; XM_001569241.1.
DR AlphaFoldDB; A4HQG6; -.
DR GeneID; 5420275; -.
DR KEGG; lbz:LBRM_35_6790; -.
DR VEuPathDB; TriTrypDB:LbrM.35.6790; -.
DR VEuPathDB; TriTrypDB:LBRM2903_350080800; -.
DR InParanoid; A4HQG6; -.
DR OMA; ANMNAHR; -.
DR Proteomes; UP000007258; Chromosome 36.
DR CDD; cd07061; HP_HAP_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR000560; His_Pase_clade-2.
DR InterPro; IPR029033; His_PPase_superfam.
DR PANTHER; PTHR11567:SF110; ACID PHOSPHATASE 1, ISOFORM B; 1.
DR PANTHER; PTHR11567; ACID PHOSPHATASE-RELATED; 1.
DR Pfam; PF00328; His_Phos_2; 2.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT REGION 417..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 441 AA; 48469 MW; F3ED8764F31E6459 CRC64;
MVQVAHRHGA RSALVDDNAT QICGTVYPCG ELTDEGVEMV RAIGKFARGR YNDPSLVESP
LFPSTRYNSS VVYTRSTDTQ RTIQSATAFL HGLFEDDYFF PVVYSHNMTT DTLLSTDTVP
SVMGRSWLDS PALSATLNPV VDAHLTWDAI QAAAKDAWIE GLCADPNARA DCVLNLYDVA
AAFEASGRLD STSDLKAAYP GLVEVNAAWY KYVFGWNDTD KLDRTQGTPS QNLAQTMLAN
MNAHRLSPSY KLFEYSAHDT TIAPLAVTFG DQGNTTMRPP YAVTIFVELL QDTEDANGWY
VRLIRGNPVK AANGIYVFQQ SGIEVHCMDS AGNMYIASTG ICPLDNFRRM VDYSRPTVED
GNCAMTTTQY SNMGCPRTIA DNEPVPLRCE VYRRVCTNKA CPPAHILSAA DYQCHPTAET
QGPSSSTNSA ARQQQRHHDS T
//
