ID A4HRD0_LEIIN Unreviewed; 272 AA.
AC A4HRD0; A0A2K4YJU8; A0A381M8V8;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Thymidylate kinase-like domain-containing protein {ECO:0000259|Pfam:PF02223};
GN ORFNames=LINJ_01_0090 {ECO:0000313|EMBL:CAM65160.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM65160.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM65160.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM65160.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM65160.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM65160.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC {ECO:0000256|ARBA:ARBA00009776}.
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DR EMBL; FR796433; CAM65160.1; -; Genomic_DNA.
DR RefSeq; XP_001462622.1; XM_001462585.1.
DR AlphaFoldDB; A4HRD0; -.
DR SMR; A4HRD0; -.
DR STRING; 5671.A4HRD0; -.
DR GeneID; 5066145; -.
DR KEGG; lif:LINJ_01_0090; -.
DR VEuPathDB; TriTrypDB:LINF_010005800; -.
DR eggNOG; KOG3327; Eukaryota.
DR InParanoid; A4HRD0; -.
DR OMA; VDRWWCS; -.
DR OrthoDB; 168156at2759; -.
DR Proteomes; UP000008153; Chromosome 1.
DR GO; GO:0050145; F:nucleoside monophosphate kinase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039430; Thymidylate_kin-like_dom.
DR InterPro; IPR014505; UMP-CMP_kinase_2.
DR PANTHER; PTHR10344; THYMIDYLATE KINASE; 1.
DR PANTHER; PTHR10344:SF5; UMP-CMP KINASE 2, MITOCHONDRIAL; 1.
DR Pfam; PF02223; Thymidylate_kin; 1.
DR PIRSF; PIRSF019736; dTMP_TKRP1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
FT DOMAIN 70..245
FT /note="Thymidylate kinase-like"
FT /evidence="ECO:0000259|Pfam:PF02223"
SQ SEQUENCE 272 AA; 29452 MW; CC0C53083C2EFB07 CRC64;
MPSIAALART LHGGTNVYRS RLDCLKVLHA VEQPPPPWWT PDCSDFVRQA ESLSTSASST
AARKNPVVVV EGLDGTGKTL VTRTLAEKLS GVAISTPPPQ FAEIRSTFRG QEEAVARAFY
SAANYIAAAS ILAASQSSVV VVDRWWCSTC AMALANGCCY DSLPPSGDAV YRWPEDLPAP
DAGFLLCVDE AVRVARIRRR APEDAEERRL SSHSEMRRVA MEAYRRTNML TEVAAPSYRV
AVNSILRLLS ESGVAHGAAP FAQAELDSIE PF
//
