ID A4HSQ1_LEIIN Unreviewed; 663 AA.
AC A4HSQ1; A0A2K4YL98; A0A381M9M7;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=ATP-binding cassette protein subfamily G, member 2 {ECO:0000313|EMBL:CAM65440.1};
GN Name=putative ABCG2 {ECO:0000313|EMBL:CAM65440.1};
GN ORFNames=LINJ_06_0090 {ECO:0000313|EMBL:CAM65440.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM65440.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM65440.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM65440.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM65440.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM65440.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FR796438; CAM65440.1; -; Genomic_DNA.
DR RefSeq; XP_001463092.1; XM_001463055.1.
DR AlphaFoldDB; A4HSQ1; -.
DR SMR; A4HSQ1; -.
DR STRING; 5671.A4HSQ1; -.
DR GeneID; 4961331; -.
DR KEGG; lif:LINJ_06_0090; -.
DR VEuPathDB; TriTrypDB:LINF_060005900; -.
DR eggNOG; KOG0061; Eukaryota.
DR InParanoid; A4HSQ1; -.
DR OMA; WMFFAIS; -.
DR OrthoDB; 4261727at2759; -.
DR Proteomes; UP000008153; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR48041; ABC TRANSPORTER G FAMILY MEMBER 28; 1.
DR PANTHER; PTHR48041:SF102; TRANSPORTER, PUTATIVE-RELATED; 1.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:CAM65440.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008153};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
SQ SEQUENCE 663 AA; 73837 MW; 6AA3CD0B9D320187 CRC64;
MPPPAATRAP TDDTYTEYSF SPIDIHEPDA PHHQRRDSGK VGAQLHGSIV EFDSSTPLAI
GVPNSYSLPL SWHRLSYSVG KKRILCGLTG TALPGRCLAI LGSSGAGKTT FLNAICDRLA
SGGELKLSGR RQLGDCEFER HFRKAMGFVA QDDIISPLST PYDALWFSLR TRRGTGRAET
EERVQEMLSV LRLRHCRGTK VGIPGLEAGL SGGERKRCSI GIELICDPKI LLLDEPTSGL
DSVTSAKVVH LLRQLSRTGR TVIYTIHQPT AEVLSYFDDV MLMTQGRIAY HGTMAASLDY
FESIGFPCPS KYTPTDYYMV LLQDSVTSKV LIKRWRKYLK NGPRTPHTAA VRFAKSRSES
SAARFLDAYI VKFGSSPAVQ LYELTRRTMM EISRDSLYLF SYTAQAIFFA AVVGLIFLNV
RANVEGIQDR QGVLFMTVMN RAMSSTFIMI NTFNNVRAVF MREQQAGAYS PLMFFLGRSF
AEFPVQILAV LVESCILYWM VGLHRHPGSF FYYFGVIALL SQVATGLGFA ISTSCPSLVV
SSAMAPLILI PLALGGGLFA STDRLRPHWY WLEKPSFMRH AYILVLRNEL HNVPHIACDY
YRWGDGYCIN QPRDGRTVMR LLGFDGDAQS ASVYMWVSLV IMFFLLRTIS VIALAVAGRR
RTA
//
