ID A4HSZ5_LEIIN Unreviewed; 891 AA.
AC A4HSZ5; A0A2K4YLJ7; A0A381M9X2;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=Putative kinesin {ECO:0000313|EMBL:CAM65538.1};
DE EC=3.6.4.4 {ECO:0000313|EMBL:CAM65538.1};
GN ORFNames=LINJ_06_1070 {ECO:0000313|EMBL:CAM65538.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM65538.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM65538.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM65538.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM65538.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM65538.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR EMBL; FR796438; CAM65538.1; -; Genomic_DNA.
DR RefSeq; XP_001463186.1; XM_001463149.1.
DR AlphaFoldDB; A4HSZ5; -.
DR SMR; A4HSZ5; -.
DR STRING; 5671.A4HSZ5; -.
DR GeneID; 4961403; -.
DR KEGG; lif:LINJ_06_1070; -.
DR VEuPathDB; TriTrypDB:LINF_060016100; -.
DR eggNOG; KOG0244; Eukaryota.
DR InParanoid; A4HSZ5; -.
DR OMA; QYVEVYG; -.
DR OrthoDB; 152053at2759; -.
DR Proteomes; UP000008153; Chromosome 6.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47969; CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED; 1.
DR PANTHER; PTHR47969:SF15; ZGC:66125; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Hydrolase {ECO:0000313|EMBL:CAM65538.1};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
FT BINDING 81..88
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 891 AA; 94754 MW; ECA141DF031F5509 CRC64;
MSERVHVVVR IRPFIASDPP DAELNTLVLD PTHVSVGNNR VFKADRVYMM EDATEVIYAE
SIAPLISRFL RGFNTSVLAY GQTGTGKTFT VQSLLPLLLT DIMADKGLRS GAAGAPSAET
STSLTAKAPL LYLQYVEVYG ETIRDLLEGP AAAALRSDGE EPSKIRLVTT TAPGARATSP
SSERADRQLS PIDERDAAAS PTAGCVLVGA TIVPIFTLAQ AAELIARGGT RRATGSTNVH
AHSSRSHAIL TLFHARYACR LDVVDLAGSE REKKTGNVGV RFQESIAINT GLLALGNVMR
ALSRIHRAAN GKEAGRGGGA GHQRAQHVPY RSSRLTRLLQ DTLGGNSATV LIACVAPDTY
NRDETLRTLQ YCSLALRILN EPLQQYERLR RAQSPLCRRG SPSAAAAVSP LSLREGSYTA
TAATRACRDS EEADEPKMTQ LKVLELQSAY ASLQQQYDEQ AEVIANMCAS HATTKERLAL
CERELRKDEG IFTQQIRAMQ ELVCENRKLR RRLAKVCAPP TTTTNTTAAA TAGRDKAAMA
HDPLFRGGDG LPESTCTETD SHHGDKDLTD AVRHLLLAGD RDAAGRMGVS LQLAPSHSQG
HRQQHSAPVA AAAATRPPLS AHSPHRSQDV RDGVTGGTQY VPLEELPLAV AHQAGVRVDD
GRGGAETPTY PGAGGRTEAS HALDGMTPGG AAAPTPAEPA QSFIRYILGL HGIDPEAEQA
GDVDGDDGRG RAGAGAVAVA ATSLQSSIRK SAATSVGGVA LEPAEVSETT AGSSRDDHAR
QEGAPSPLNY ALSRRSGRFA ASFPPQTMGA LSEGEHSSWE RQVDRRGGGA DAAQLDSSAV
LLLAKEVLRY QGTNAELRNQ VQVLQAELDG KQREAALLRL ELQEMKELFT T
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