ID A4HTD5_LEIIN Unreviewed; 417 AA.
AC A4HTD5; A0A2K4YM18; A0A381MBY9;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Putative delta-5 fatty acid desaturase {ECO:0000313|EMBL:CAM65683.1};
DE EC=1.14.99.- {ECO:0000313|EMBL:CAM65683.1};
GN ORFNames=LINJ_07_1260 {ECO:0000313|EMBL:CAM65683.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM65683.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM65683.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM65683.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM65683.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM65683.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family.
CC {ECO:0000256|ARBA:ARBA00009295}.
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DR EMBL; FR796439; CAM65683.1; -; Genomic_DNA.
DR RefSeq; XP_001463326.1; XM_001463289.1.
DR AlphaFoldDB; A4HTD5; -.
DR STRING; 5671.A4HTD5; -.
DR GeneID; 5066669; -.
DR KEGG; lif:LINJ_07_1260; -.
DR VEuPathDB; TriTrypDB:LINF_070017500; -.
DR eggNOG; KOG4232; Eukaryota.
DR InParanoid; A4HTD5; -.
DR OMA; LSANWWN; -.
DR OrthoDB; 294339at2759; -.
DR Proteomes; UP000008153; Chromosome 7.
DR GO; GO:0016717; F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; IEA:UniProt.
DR GO; GO:0006636; P:unsaturated fatty acid biosynthetic process; IEA:UniProt.
DR CDD; cd03506; Delta6-FADS-like; 1.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR005804; FA_desaturase_dom.
DR InterPro; IPR012171; Fatty_acid_desaturase.
DR PANTHER; PTHR19353:SF88; DELTA(5) FATTY ACID DESATURASE FAT-4; 1.
DR PANTHER; PTHR19353; FATTY ACID DESATURASE 2; 1.
DR Pfam; PF00487; FA_desaturase; 1.
DR PIRSF; PIRSF015921; FA_sphinglp_des; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:CAM65683.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
FT DOMAIN 134..393
FT /note="Fatty acid desaturase"
FT /evidence="ECO:0000259|Pfam:PF00487"
SQ SEQUENCE 417 AA; 48249 MW; 4D511F1F7B7A450E CRC64;
MAPDNARPHQ RNEVLIDGVL YDCTDFRHPG GSILKYYLGS GDATETYQQF HLKLPRADKY
LKRLPNRPAP PQHGVDVDEQ KRLAKLSRDF KALHDACVEE GLFNASWPHI VYRFSELILM
HAIGLYMLFH LPMLWPIALV ILGVAEGRCG WWMHEAGHYS VTGIPWLDIK IQEVLYGLGD
GMSASWWRSQ HNKHHATPQK HRHDVDLETL PLVAFNKIIA LRGKRNANIR RWISLQMFLF
GPVTCSLVAL YWQLFLHVRH AMRTQRYTEG VAILCRWIAV GVICHKLQVS FWQGLGGVLF
SQAFSAAYIF INFALNHSHL PMLPEDEHAH FVEYAAIYTM NVTPSWFVTW FMGYLNYQVE
HHLFPTMPQF RFVQLAPRVR KLFEENGLKY DSRPYMKSLQ KTFKNLGDVA ELIVAGN
//
