ID A4HU46_LEIIN Unreviewed; 2512 AA.
AC A4HU46;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CAM65952.1};
GN ORFNames=LINJ_09_1300 {ECO:0000313|EMBL:CAM65952.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM65952.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM65952.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM65952.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM65952.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM65952.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796441; CAM65952.1; -; Genomic_DNA.
DR RefSeq; XP_001463587.1; XM_001463550.1.
DR AlphaFoldDB; A4HU46; -.
DR SMR; A4HU46; -.
DR STRING; 5671.A4HU46; -.
DR GeneID; 5066993; -.
DR KEGG; lif:LINJ_09_1300; -.
DR VEuPathDB; TriTrypDB:LINF_090019700; -.
DR eggNOG; KOG1802; Eukaryota.
DR InParanoid; A4HU46; -.
DR OMA; QMSEWEV; -.
DR Proteomes; UP000008153; Chromosome 9.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
FT DOMAIN 1914..2145
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 2153..2390
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 27..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 133..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1244..1297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1321..1349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1382..1418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1648..1671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2030..2066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2333..2355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1253..1273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1280..1294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1401..1418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2335..2355
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2512 AA; 268693 MW; 7ECEF012ACCC8640 CRC64;
MNAYSLHGKR CADPSHWPQW IPLTGESNAS LPVPPQPPSS TLSTNATSSP GIDEHSREAC
MNALLQYVTQ WMAILPSGVS SGTEAALHGA GIATGTFSMN ATDSACASLS VQPVAMLNAM
LVSLPTAVAA PPVQGRQQGA ASPPRPEEAA EPGSSLTSTK VPELTPIIED TPARPPQLLD
VAAQLLRHSK WLASGLSHAA GPAPRLPSSA LVSHAYQHAL LAACSSDWVM QFRRAYKAGT
ATDSTTTAKA DARGLTAPLP WTLPPAVLAE SSTSGYVMQP IEGYRGTLVL LLFHPLRVVR
VWARDVLLRL MTCTAPQHEA SAPGESSSDG GERALATLLS FSLRLLCTLK HVSVLPAQVS
FISLHEHPSW TASAAPERHV DAVKYVMQDR IHTVVDGIFH LLTVLTAWDM HFGKAVEALT
MTSTATVDRA SATSMPILLG KCRATVLLLG GSLVLYGLQG LHQGIHRALL EAWRDQQHRH
LRSSSARGDL FCASQAAMTQ LLGPLNTLLS SNPRMPRANA VAATAIRKAL AKVLVHCLLD
NASGLASSKE EEAWRRARLE WLWMFAAALE PPTPRAAAPL LADGPNASAP SSADHTGTAA
PEHQGSGTTK ATGQDDVGTG TLVWVPERCA GWLLRPLLKN AAQQFQWAKA MVAAKAKPSA
GGAATASDGT DSAIAVLDKA VYGVSMLLDS LATALPRLVR STYLHDTLVA HESQLLTLAI
GGIVHTRSTH ALRLHRLLFH ADVHAFAAGA AAQGRGGTAP AGTLGVPSVC LQRLWLTLPT
LIVQVCKSGA VSPADCGGHA GSAISGGPLP LSEVVASLCG ALTVLAEEDA MPCPQWLFMS
PAKVMSRAPP PFQWVVQRCL RTLAGTLQEQ QELLKRVWLR LPSAPTEAAY ASAAAAAASR
ALTQERPLLR LLFALRVAAA EDAEAGKLAE RLTAVFCVGV TSSVSRTLST EAAMWVWRRV
VVTQPELRLY PPPPSTASTA AAAAAAGDGA YAAWDMNDAV VTSTARAQGH RWLVLLCACH
FDQMSEWEVQ CGWWMAALLA DVVTLDVEQR RALAEQVILA LPTAPMLALS EAATHAVGST
HPPVEEAAEG QCGAIEKKGE HQLRDKGAES AQHRHSVVQR LLIHVLRKAE QYPQASLASV
LLRISDALPP AVAARDVQFQ QQVQPLLVQL CARSPDVQKC LTRNGAMWLR RCTEQATQTI
NECLAEQERR FRQFELEEAT LRREEVEAAQ AAVAAERLRH ANEAKRTAEL GQQRAVKRST
AASEVSQSGS DGGVVSLPMR KPTTTVSHHS DHGSSAVAAT RRDLRQQQLF PDLSLAHLAV
KRERTPPVDG ADMRSPKSVP PRPADNGSSA MIALNVDSDE EDVMVAASTV QLLGSFARPA
SPCAVTPPSP ASAPAPLAKA PKTSPSTTAS TTARAAPTRL QHKLQEINAR NTHRVHHAEQ
LRQLQERLRR VAISTNLLHL QPPLVHDIVG PASQCMAPEV PVLPEVFVSA SDGFRRVSFD
GSAASAGGAS LNASATMPFG DAASEYAVRF APHIALELRY DIIRNYEDFL DDVCKGHDGR
DTNSSHYYRH SAATAPVTAG EGASPSPVNG LWNSLLPLHP GIPPACVAVQ SSCAASRGHS
GEAMPGPQTL HFDVRACANP AVDVYLQRQQ QRAQDTHSSA QRSSTTSTTM HPKSVHAVVV
AAAQQGLSAA FSEGDVVAVL LPLQTILAKW AERELRRPLS DCPVAELEHR VLEMLDTLPR
SWRTLGCAVQ VCEVQSLSPG GRAAHLCATP SVVEQSSGGH GPPSLRFSHV FRMAYDTTSS
PTFYVTKLTS VNASLMELEA LHKIDRTRFA ATLYDPRSTA PVGVAFCGWA NSLLSTAGPS
CTVPLLDQLR ARLLLQQQLN DWQARAIVAV LYAACPGWDD GVAEQSTRAP VPRAPEMLVI
EGPPGTGKTQ TIGLLTLNLL HHLSRTWGTA RRILVCAPSN CGVDEALLRV VRLREQLRGA
APGGALPPAH AVLAGGLLRI GVRDRVDREV LRLQEPVFFD DVVERHLSGT PATAESLRRG
ERAGGSRDSA SPRGHNAGGN GTASGRAAVR SAIRTHTLES AAIVFSTLGS LHHIGRQVQG
IAFDVVIVDE ASQGTEPAVL QAVALAKSKS VLVGDSRQLQ PTVLSWEASR CGLRRSLLVR
LLACGHPSFL LRTQYRMHPD IAAFPNEYFY GSKLLTDRSV LARSRAPDSP TAAPATIAQK
LGRCPRFVFV DVRDSPMERR RGRSLLNRRE ATAVVDCMRQ LRAFFKMTVR EMAAHVGIIT
FYTAQRETIL STLTQEERHS GVQVATVDSF QGKEKRIILL SCVRTLSAAQ LQRRAAQGEK
ERNSDDSDGV AREERSANRR LGRYGLGFLA DWHRLNVALT RAQDLCVCFA SRDTVRAVGM
AAMASAAPAN AVTTVDSSAE EVEHQLDADD EDPLALYRML AHAETRDPTL QPPASEPVLL
EASTDSVEIV DAPGASRSRA ACLTYRCKAH LVSELTARAG AAQARDDLRS AQ
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