ID A4HUG9_LEIIN Unreviewed; 478 AA.
AC A4HUG9; A0A2K4YN42; A0A381MBG5;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 24-JAN-2024, entry version 82.
DE SubName: Full=Zinc-binding dehydrogenase-like protein {ECO:0000313|EMBL:CAM66077.1};
GN ORFNames=LINJ_10_0620 {ECO:0000313|EMBL:CAM66077.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM66077.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM66077.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM66077.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM66077.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM66077.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796442; CAM66077.1; -; Genomic_DNA.
DR RefSeq; XP_001463710.1; XM_001463673.1.
DR AlphaFoldDB; A4HUG9; -.
DR SMR; A4HUG9; -.
DR STRING; 5671.A4HUG9; -.
DR GeneID; 5067081; -.
DR KEGG; lif:LINJ_10_0620; -.
DR VEuPathDB; TriTrypDB:LINF_100012500; -.
DR eggNOG; KOG1198; Eukaryota.
DR InParanoid; A4HUG9; -.
DR OMA; QLAHYFG; -.
DR OrthoDB; 146242at2759; -.
DR Proteomes; UP000008153; Chromosome 10.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR44013; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C; 1.
DR PANTHER; PTHR44013:SF1; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
FT DOMAIN 59..424
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 478 AA; 51085 MW; 92AA71AA78CFE5E0 CRC64;
MGHKNSSNIS SAPVPPPFYV LPAVPVPSLK PSNLDFSETS GKPILCAGWI APHGNRSWSR
RNVVYSSEIE VPVPQPCQVR VKIYAAGVNP VDAHRTAVLT SFPEVGTSGK SRCASRHPRP
PFKFPYVVGI EGAGVVESVG WAATSSGERD GSAGAPASAN ARDIRVGDRV AFLADFTQGS
GGTFCQYAVV DSDVLWKLPE VVCAPPPSTD GLVPGRLIDF VEAASLPAAA ATAYIALFDK
LRIETQRAIF ISGASGGVGS AAVQLAHYFG LYVIASCSTP NMRYVQSLGA DYVVDYTRAD
VVKEILTYTD NYGVDYLLEC AGASMAEAHS ETVRFGGALC VLTGLLSPRS DMVFRRQLSV
HYVCLGMQHQ DPLARTQLQP LGELVMQLYI QGAFSVNAEQ VPFVQAADAL DVVALGHGRG
KIVLTNFHTN EDKEERLRRR HVQLYEKAQR QYQLEETQKA AGAAAAAAAS DAASREAG
//
