ID A4HUU6_LEIIN Unreviewed; 253 AA.
AC A4HUU6; A0A2K4YNI4; A0A381MEH2;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Putative 14-3-3 protein {ECO:0000313|EMBL:CAM66207.1};
GN ORFNames=LINJ_11_0350 {ECO:0000313|EMBL:CAM66207.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM66207.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM66207.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM66207.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM66207.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM66207.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the 14-3-3 family.
CC {ECO:0000256|ARBA:ARBA00006141}.
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DR EMBL; FR796443; CAM66207.1; -; Genomic_DNA.
DR RefSeq; XP_001463837.1; XM_001463800.1.
DR AlphaFoldDB; A4HUU6; -.
DR SMR; A4HUU6; -.
DR STRING; 5671.A4HUU6; -.
DR GeneID; 5067213; -.
DR KEGG; lif:LINJ_11_0350; -.
DR VEuPathDB; TriTrypDB:LINF_110008400; -.
DR eggNOG; KOG0841; Eukaryota.
DR InParanoid; A4HUU6; -.
DR OMA; KGCQLAR; -.
DR OrthoDB; 920089at2759; -.
DR Proteomes; UP000008153; Chromosome 11.
DR CDD; cd08774; 14-3-3; 1.
DR Gene3D; 1.20.190.20; 14-3-3 domain; 1.
DR InterPro; IPR000308; 14-3-3.
DR InterPro; IPR036815; 14-3-3_dom_sf.
DR InterPro; IPR023410; 14-3-3_domain.
DR PANTHER; PTHR18860; 14-3-3 PROTEIN; 1.
DR PANTHER; PTHR18860:SF17; 14-3-3 PROTEIN EPSILON; 1.
DR Pfam; PF00244; 14-3-3; 1.
DR PIRSF; PIRSF000868; 14-3-3; 1.
DR PRINTS; PR00305; 1433ZETA.
DR SMART; SM00101; 14_3_3; 1.
DR SUPFAM; SSF48445; 14-3-3 protein; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
FT DOMAIN 11..248
FT /note="14-3-3"
FT /evidence="ECO:0000259|SMART:SM00101"
FT SITE 64
FT /note="Interaction with phosphoserine on interacting
FT protein"
FT /evidence="ECO:0000256|PIRSR:PIRSR000868-1"
FT SITE 136
FT /note="Interaction with phosphoserine on interacting
FT protein"
FT /evidence="ECO:0000256|PIRSR:PIRSR000868-1"
SQ SEQUENCE 253 AA; 29217 MW; A13C2276D284BD4D CRC64;
MTNVFKVPEK REELVYTAKI AEQCERHDEI LFCMKRAVKM NPRLSSEERN LLSAAYKYII
SARRACWRSM SSMAHKEDSH KGKTASLFNG FQHQVEKELA EICSDILELL DKYLIPAADN
DESKVYYYKL KGDYHRYFAE VESGSDTQKN LALEAYKKAS EFTTSLKPTS PIRLGLALNF
SVFYYEILRS PDKGCQLARQ AFEEALSDPE VLDEEQHKES ALIMQLLRDN LALWTEDSRP
EGQDDETAME ELE
//
