ID A4HVR7_LEIIN Unreviewed; 404 AA.
AC A4HVR7; A0A2K4YPK0; A0A381MFF4;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 24-JAN-2024, entry version 79.
DE RecName: Full=Metallo-beta-lactamase domain-containing protein {ECO:0000259|Pfam:PF12706};
GN ORFNames=LINJ_13_1290 {ECO:0000313|EMBL:CAM66534.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM66534.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM66534.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM66534.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM66534.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM66534.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FR796445; CAM66534.1; -; Genomic_DNA.
DR RefSeq; XP_001464158.1; XM_001464121.1.
DR AlphaFoldDB; A4HVR7; -.
DR SMR; A4HVR7; -.
DR STRING; 5671.A4HVR7; -.
DR GeneID; 5067540; -.
DR KEGG; lif:LINJ_13_1290; -.
DR VEuPathDB; TriTrypDB:LINF_130019100; -.
DR eggNOG; KOG3798; Eukaryota.
DR InParanoid; A4HVR7; -.
DR OMA; QHWTRRT; -.
DR OrthoDB; 226459at2759; -.
DR Proteomes; UP000008153; Chromosome 13.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR15032; N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D; 1.
DR PANTHER; PTHR15032:SF4; N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D; 1.
DR Pfam; PF12706; Lactamase_B_2; 2.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
FT DOMAIN 121..251
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF12706"
FT DOMAIN 294..362
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF12706"
SQ SEQUENCE 404 AA; 45139 MW; FE8F8A310BCB08B8 CRC64;
MPESVQPKPG FEYPKRAAIG SYWSNRNRDG KHFKNLGLAS SSSASAGKVM QWMLSHSCNG
VPKPKGGYDA FGKIWYAPCN MAESVAQWRA SMSNDEAQPA KNRVYWIGHS SQLLCLSNGV
NVLFDPIFSQ RASPLSFAGP SRRFPPAATA AQLPPIHIVT VSHNHYDHMD KQSIKAVAVR
FPDAQFVVPL KLDRFLREWG VPAASITTLD WYEACEVKGV RVGCTPAQHW GKHSAFDDNE
VLWCGWCVGW QPGQQQHQQK PASTCEKPTL ISSSGIGSSS EVLVEAQRTW NRYKKYFFAG
DTAYNPDVST SIYAHFGPMD MAALPIGAYS PRWFMARAHI DPEHAVQIFQ DQHIQQAVAV
HWGTFELADE PLDEPPQVLR KTLKDASIDE SRFQIIPMGK FIEF
//
