ID A4HVT9_LEIIN Unreviewed; 728 AA.
AC A4HVT9; A0A2K4YPJ8; A0A381MFL8;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE RecName: Full=Kinesin-like protein {ECO:0000256|RuleBase:RU000394};
GN ORFNames=LINJ_13_1350 {ECO:0000313|EMBL:CAM66557.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM66557.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM66557.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM66557.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM66557.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM66557.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283,
CC ECO:0000256|RuleBase:RU000394}.
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DR EMBL; FR796445; CAM66557.1; -; Genomic_DNA.
DR RefSeq; XP_001464180.1; XM_001464143.1.
DR AlphaFoldDB; A4HVT9; -.
DR SMR; A4HVT9; -.
DR STRING; 5671.A4HVT9; -.
DR GeneID; 5067563; -.
DR KEGG; lif:LINJ_13_1350; -.
DR VEuPathDB; TriTrypDB:LINF_130021600; -.
DR eggNOG; KOG0246; Eukaryota.
DR InParanoid; A4HVT9; -.
DR OMA; MPTEHIE; -.
DR OrthoDB; 239968at2759; -.
DR Proteomes; UP000008153; Chromosome 13.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd01367; KISc_KIF2_like; 1.
DR CDD; cd09541; SAM_KIF24-like; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR47971:SF8; KINESIN-LIKE PROTEIN KIF24; 1.
DR PANTHER; PTHR47971; KINESIN-RELATED PROTEIN 6; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Microtubule {ECO:0000256|RuleBase:RU000394};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
FT BINDING 289..296
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 728 AA; 80814 MW; CF80DE80F3B4041B CRC64;
MESQLKQLLV QGGLEHTVQG FVDGGVTSVQ QLKQLTMQDY HSVGVIVMTD RRKLFELIQF
LKRDRANGSG GGMTPAAPVA STGPKSPPPA TEPASRVQAA IQAPALPARI PTPLRRATPT
EAMQRRERER VAEQPRPMSA QRRDPNTDDG ENAVRPAAAP AKPVSRPVSR VGASSPSPFG
RRATGEGGNA QRRRASRITV VIRKRPLNAS EQADGLYDIL ATDPDNNHII TLLEPRQKVD
LTRYIEKHRF TYDKVMDDRK TNRDVYEEAC KPLIETVFEG GCATCFAYGQ TGSGKTYTML
GKDKQEGLYL MAAKDLWSRL SRGMGINVSF FEIYGGKLYD LLNERERLAC REDSRGVINV
CGLTEHRVDS TDHLMEIIDY GNTIRAAGST GMNADSSRSH AILHITIVNE KNRFFGRFTF
IDLAGSERGA DTLDSDRTTR LEGAEINKSL FALKECIRAL DQNHRHIPFR GSKLTAVLRD
CFMGNSRTVM IGNISPASGS CEHTLNTLRY ADRVKELKKD KSSHSAAEEI MMGQMPTEHV
ETVGISGSFA QRRAKERVIT SSRSSSQTRT REPGTPNQKM VNSFHRHGDD SSDNTLRSNR
SFGSRPVTSS SPQKKSYHRP TPTHSRGPSG MSSAMPTPMG DDSRYDSGDS LDAEEDNLIL
AHRHHIDCMM ELLKDEMTQL NAAENPENSM SGYCRRVDAI LSSQVRRIEE LRRQLDQYTR
HAGAAGRR
//
