ID   A4HWL6_LEIIN            Unreviewed;       833 AA.
AC   A4HWL6; A0A2K4YQJ2; A0A381MEG1;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=MGT1 magnesium transporter {ECO:0000313|EMBL:CAM66845.1};
GN   Name=MGT1 {ECO:0000313|EMBL:CAM66845.1};
GN   ORFNames=LINJ_15_1330 {ECO:0000313|EMBL:CAM66845.1};
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM66845.1, ECO:0000313|Proteomes:UP000008153};
RN   [1] {ECO:0000313|EMBL:CAM66845.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM66845.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM66845.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM66845.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC       family. {ECO:0000256|ARBA:ARBA00009765}.
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DR   EMBL; FR796447; CAM66845.1; -; Genomic_DNA.
DR   RefSeq; XP_001464457.1; XM_001464420.1.
DR   AlphaFoldDB; A4HWL6; -.
DR   STRING; 5671.A4HWL6; -.
DR   GeneID; 5067851; -.
DR   KEGG; lif:LINJ_15_1330; -.
DR   VEuPathDB; TriTrypDB:LINF_150020900; -.
DR   eggNOG; ENOG502R8TN; Eukaryota.
DR   InParanoid; A4HWL6; -.
DR   OMA; QWKRVIE; -.
DR   OrthoDB; 5491551at2759; -.
DR   Proteomes; UP000008153; Chromosome 15.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015693; P:magnesium ion transport; IEA:UniProt.
DR   Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 1.
DR   InterPro; IPR045861; CorA_cytoplasmic_dom.
DR   InterPro; IPR045863; CorA_TM1_TM2.
DR   InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR   PANTHER; PTHR46494; CORA FAMILY METAL ION TRANSPORTER (EUROFUNG); 1.
DR   PANTHER; PTHR46494:SF1; CORA FAMILY METAL ION TRANSPORTER (EUROFUNG); 1.
DR   Pfam; PF01544; CorA; 1.
DR   SUPFAM; SSF143865; CorA soluble domain-like; 1.
DR   SUPFAM; SSF144083; Magnesium transport protein CorA, transmembrane region; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008153};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ   SEQUENCE   833 AA;  92514 MW;  8F99D453F93F7DCC CRC64;
     MSSNASTETP ASLRAEEVTM TSPDRLTNLG TSTFLTPPSV EHPSAASELG SSHAPLPPRV
     QNLANVVVPL ASAEARVSNA HSYARRPLEI VESIRGLHEL HQKGGLTREE FAQAKQQILD
     SAASSASTYK SKSKRSRGRR HRRRGRRSRN TSRSASTSTC TRPSRDARSR ATTGVDPRSA
     SHRPSRSSSS SKSSSSSSSS SNRFIIVPRS NVWRTLNDPI EEGLLGHHLT EGHHLRVAYN
     DAPRLVRSPL LSRGGAVVGF GSRERGGQEE CCAGAHGRHG YQEIPSEDPL TSNLASGAAV
     PTPTLATAAD TKDGPFASPS GSAIGAATAA TGSSVARYAT SATVPDGRGK AKYGAFLHRD
     DGARAGGPAP HIHAVLNKED VVCIQYFNSR GGSGNHFRDV ELHTSQLRDP IFVHKGQSQV
     IPAKPRTSVT KPGHDEPVMM AMPTRDSQVF QLAEMTLEER RAWEEMTTTH SSSSKSRRAK
     SSYFEQSFNW YWVDVTGRDA SRQQYNATLR YLTNRFKLCE SFLVDRDHTL VLPQVCESPI
     YAGQYLLNLR VATEKIAISD DSVMELTNRW IIVVDLKQHI VITLHRVDTH SMANLRSQWK
     RVIENSNVSF QEFLLKIIDD AIYTYHLSLD VHTALLEKCE AKLFVEKPAV TTPEVSGHYI
     DKRILHHFAG SSRSPFLRRL LDEQDRSPMN KGEMNSFLHH LHRRTSVQHR MINVTQAVLA
     KAFTKLRLCS REMAGQMCAS CIEISDRALE VRDDAKTLLN LHISLQSFRT TELMAVLTRV
     TMLFTPVTFL AGVYGMNFQK NFPELTWDYG YAFFWTLCII LVIAMHVLFV REH
//