ID A4HZ10_LEIIN Unreviewed; 401 AA.
AC A4HZ10; A0A2K4YT55; A0A381MJ49;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Putative aminoacylase {ECO:0000313|EMBL:CAM67551.1};
DE EC=3.5.1.14 {ECO:0000313|EMBL:CAM67551.1};
GN ORFNames=LINJ_20_1720 {ECO:0000313|EMBL:CAM67551.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM67551.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM67551.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM67551.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM67551.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM67551.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796452; CAM67551.1; -; Genomic_DNA.
DR RefSeq; XP_001465301.1; XM_001465264.1.
DR AlphaFoldDB; A4HZ10; -.
DR SMR; A4HZ10; -.
DR GeneID; 5068719; -.
DR KEGG; lif:LINJ_20_1720; -.
DR VEuPathDB; TriTrypDB:LINF_200022000; -.
DR eggNOG; ENOG502QQEM; Eukaryota.
DR InParanoid; A4HZ10; -.
DR OMA; RIIHQPA; -.
DR OrthoDB; 3684955at2759; -.
DR Proteomes; UP000008153; Chromosome 20.
DR GO; GO:0004046; F:aminoacylase activity; IEA:UniProtKB-EC.
DR CDD; cd08021; M20_Acy1_YhaA-like; 1.
DR Gene3D; 3.30.70.360; -; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR017439; Amidohydrolase.
DR InterPro; IPR036264; Bact_exopeptidase_dim_dom.
DR InterPro; IPR002933; Peptidase_M20.
DR InterPro; IPR011650; Peptidase_M20_dimer.
DR NCBIfam; TIGR01891; amidohydrolases; 1.
DR PANTHER; PTHR11014:SF63; METALLOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09600)-RELATED; 1.
DR PANTHER; PTHR11014; PEPTIDASE M20 FAMILY MEMBER; 1.
DR Pfam; PF07687; M20_dimer; 1.
DR Pfam; PF01546; Peptidase_M20; 1.
DR PIRSF; PIRSF005962; Pept_M20D_amidohydro; 1.
DR SUPFAM; SSF55031; Bacterial exopeptidase dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:CAM67551.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
FT DOMAIN 189..281
FT /note="Peptidase M20 dimerisation"
FT /evidence="ECO:0000259|Pfam:PF07687"
SQ SEQUENCE 401 AA; 43557 MW; 2687BCCD172061F1 CRC64;
MSFVQTLITA VQPEVVQWRR HIHEYPYVAY EEQPTADYVA DVLSSMPAPL DIRRLTPNSV
VADLRGGAGE GPMYALRADM DALPLQEESG EPFSSKRPGV MHACGHDAHT AMLLGAVKVL
CQMRDRIRGT VRFVFQHAEE VVPSGAKQLV GLGVLDGVSM IFGLHVDVMR PSGSIWCRMG
TIMGACNDFD IVIRGAGGHA SQPELCVDPI LIASEVVANL QSVVSRRVSA LKAPVLSITT
FEGGRGSYNV IPDTVRMRGT LRCLDRDTQA RVPSLMEEII AGITKAHGAQ YELSWLEPNI
VTYNDPKAYE VAKAAAVRLV GEGNYHELST PLLGVADFSE YQAVVPGCLC WLGVGNSALG
DANNHNYSSR FRMNEAGMEL GVKHHVLIIA SLMMQTEGSK E
//