ID A4I2H5_LEIIN Unreviewed; 516 AA.
AC A4I2H5; A0A2K4YX74; A0A381MKI0;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CAM68967.1};
GN ORFNames=LINJ_26_2590 {ECO:0000313|EMBL:CAM68967.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM68967.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM68967.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM68967.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM68967.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM68967.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the D-alanine--D-alanine ligase family.
CC {ECO:0000256|ARBA:ARBA00010871}.
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DR EMBL; FR796458; CAM68967.1; -; Genomic_DNA.
DR RefSeq; XP_001470586.1; XM_001470549.1.
DR AlphaFoldDB; A4I2H5; -.
DR SMR; A4I2H5; -.
DR STRING; 5671.A4I2H5; -.
DR GeneID; 5069963; -.
DR KEGG; lif:LINJ_26_2590; -.
DR VEuPathDB; TriTrypDB:LINF_260031400; -.
DR eggNOG; KOG4442; Eukaryota.
DR InParanoid; A4I2H5; -.
DR OMA; ELTMDYR; -.
DR OrthoDB; 167616at2759; -.
DR Proteomes; UP000008153; Chromosome 26.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008716; F:D-alanine-D-alanine ligase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd20071; SET_SMYD; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR011095; Dala_Dala_lig_C.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR23132; D-ALANINE--D-ALANINE LIGASE; 1.
DR PANTHER; PTHR23132:SF28; PROTEIN WITH D-ALANINE--D-ALANINE LIGASE C-TERMINAL DOMAIN; 1.
DR Pfam; PF07478; Dala_Dala_lig_C; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008153};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 516 AA; 58869 MW; 6C08D88F54AAB4F3 CRC64;
MTDALAKPIR VCVLACSYEG SDSELRAYEG DLIQTPQNYF CSEDAQCTFH LELIKKATTY
RQIRQLVMSG KFDVFYNQCD GAKDEDRAGV EVVEALEEFK VPYTGAISKY YEMSKPDMKL
VAYYYNIATA NYVVLEPGAD IERLCGDLQF PCIIKHISGY SSVGMDKSCK VHDMAQLVDR
ATRFMAEYQF ALVEEFVSGD EATILACSDS TQPEGVRVFP PVQVAFPEGE DFKHFQLKWA
SYEGMQWTQV PQEDPALQNM IDIARSAFKR MMGGIGYGRI DVRIDRQNNN RVVFLEINPN
CGIMYPYGQE GSADWILRLN KGFQQREFAM LQIREAITRC QQQRLLYVRR FDPVRGYHLR
AAEDISVGTI IFQDECRPVR LCTKPYARQH FSKADYVDFQ HNAWPVGRDG HYYALWDHDP
AQWRAFNHSC EPNMSFAPMR SLDVVALRNI PKGEELTMDY RQFMDSTMPG FQCNCGTEKC
EGFVSPGSLT DSPTTKIASQ PTVVMHQNIA ANLNLI
//
