ID A4I324_LEIIN Unreviewed; 130 AA.
AC A4I324;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 22-FEB-2023, entry version 64.
DE RecName: Full=PH domain-containing protein {ECO:0000259|SMART:SM00233};
GN ORFNames=LINJ_27_2200 {ECO:0000313|EMBL:CAM69177.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM69177.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM69177.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM69177.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM69177.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM69177.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796459; CAM69177.1; -; Genomic_DNA.
DR RefSeq; XP_001466457.1; XM_001466420.1.
DR AlphaFoldDB; A4I324; -.
DR SMR; A4I324; -.
DR GeneID; 5070170; -.
DR KEGG; lif:LINJ_27_2200; -.
DR VEuPathDB; TriTrypDB:LINF_270030100; -.
DR eggNOG; ENOG502S4CV; Eukaryota.
DR InParanoid; A4I324; -.
DR OMA; TYSPHFC; -.
DR Proteomes; UP000008153; Chromosome 27.
DR GO; GO:0005938; C:cell cortex; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0032065; P:maintenance of protein location in cell cortex; IEA:InterPro.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR024774; PH_dom-Mcp5-type.
DR InterPro; IPR001849; PH_domain.
DR Pfam; PF12814; Mcp5_PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
FT DOMAIN 10..117
FT /note="PH"
FT /evidence="ECO:0000259|SMART:SM00233"
SQ SEQUENCE 130 AA; 15381 MW; 22F50B84C8F10D39 CRC64;
MDLRTSVETL RAGDWFYKWT SKGDSVHRRW FWIDTKSYLL VWSNYETYNP HFCGSVRLDD
ICQVTSRDLS SVDEDGFPKT YYVLLIETRK RVLQLATELK DKCDTWFEAL NNVMGFIHRN
DMARGALIPD
//