ID A4I382_LEIIN Unreviewed; 616 AA.
AC A4I382; A0A2K4YY31; A0A381MLP5;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=ATP pyrophosphate-lyase {ECO:0000256|ARBA:ARBA00032597};
DE AltName: Full=Adenylyl cyclase {ECO:0000256|ARBA:ARBA00032637};
GN ORFNames=LINJ_28_0090 {ECO:0000313|EMBL:CAM69236.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM69236.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM69236.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM69236.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM69236.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM69236.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- FUNCTION: Could act as a receptor for an unknown ligand.
CC {ECO:0000256|ARBA:ARBA00002708}.
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DR EMBL; FR796460; CAM69236.1; -; Genomic_DNA.
DR RefSeq; XP_001470044.1; XM_001470007.1.
DR AlphaFoldDB; A4I382; -.
DR SMR; A4I382; -.
DR STRING; 5671.A4I382; -.
DR GeneID; 5070229; -.
DR KEGG; lif:LINJ_28_0090; -.
DR VEuPathDB; TriTrypDB:LINF_280005800; -.
DR eggNOG; KOG0618; Eukaryota.
DR InParanoid; A4I382; -.
DR OrthoDB; 1698689at2759; -.
DR Proteomes; UP000008153; Chromosome 28.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd01040; Mb-like; 2.
DR Gene3D; 1.10.490.10; Globins; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR044399; Mb-like_M.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR46458; BLR2807 PROTEIN; 1.
DR PANTHER; PTHR46458:SF1; GEO09476P1; 1.
DR Pfam; PF00042; Globin; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF46458; Globin-like; 2.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Lyase {ECO:0000313|EMBL:CAM69236.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
SQ SEQUENCE 616 AA; 70591 MW; 7A6A5415AFD5BB7A CRC64;
MDCWNTRRDS KEFQHEVVET DSLQANCGAP NEQAFHDTLV SAAHQLRARQ RDTNVSISKA
EMEGLVVLTR ELENLKQMMK RSEFTVEGTW RILEDEGMVE RFGQQLYDEL LTRNPRLRVY
FHGVDIKEQS KSLLRMVGTA VHFYQKPQLT VDMFTKAGAR HRGYGVNAEV FVEMSNAFMR
VFSKFVGTDV FQAAEEEWRK FWKYVLDLLV HGSESPEGER YGKVYEEKML KKIQSDFKLI
MERQNRCDLR RQFVSVMYSK AMEMHEELSK FEALKDLRAS ARVLQSYIDV INNIHDKKLL
DEYMRELGGR HTAYNVTVEN LHAFTEPFLF TCRHFLEDEW NIAVESRLLW LFEYMIDGIS
AGMVSDINSI VNLRAPSNSV SFGLIFTDIE ASTRLWSKDS QSMSLAVKSH HAMIRRLIAD
YGAYEVKTVG DSFIIATKDV LVAVKLSLSI QLELMRMAPI APGFAMVDSS EGHGDPQAWD
DRTLRVRIGV EHCTDATATY DTIHRRYDYY GASVNRCARI ESAACGGQIL LSRESFEHLK
SIPEFHDEPC PYLFRSVEIA TPPPKEDSRG LDHFVVVSDV GLASFKGIAE PVHLVSLVPR
CLAGRQFTEK FTKVAE
//
