ID A4I3Y5_LEIIN Unreviewed; 937 AA.
AC A4I3Y5; A0A2K4YYV4; A0A381MPT5;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
GN ORFNames=LINJ_28_2720 {ECO:0000313|EMBL:CAM69492.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM69492.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM69492.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM69492.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM69492.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM69492.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665,
CC ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946,
CC ECO:0000256|RuleBase:RU363044};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the helicase family. PIF1 subfamily.
CC {ECO:0000256|ARBA:ARBA00009781}.
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DR EMBL; FR796460; CAM69492.1; -; Genomic_DNA.
DR RefSeq; XP_001470297.1; XM_001470260.1.
DR AlphaFoldDB; A4I3Y5; -.
DR STRING; 5671.A4I3Y5; -.
DR GeneID; 5070485; -.
DR KEGG; lif:LINJ_28_2720; -.
DR VEuPathDB; TriTrypDB:LINF_280032500; -.
DR eggNOG; KOG0987; Eukaryota.
DR InParanoid; A4I3Y5; -.
DR OMA; QLGGCTF; -.
DR OrthoDB; 169314at2759; -.
DR Proteomes; UP000008153; Chromosome 28.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23274:SF7; ATP-DEPENDENT DNA HELICASE PIF3; 1.
DR PANTHER; PTHR23274; DNA HELICASE-RELATED; 1.
DR Pfam; PF05970; PIF1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
SQ SEQUENCE 937 AA; 102169 MW; D26523F26C7EEDEC CRC64;
MEANAGAAGT REAPSAGAPC FPVPLPRVQL PMEFAPLQKE PTFRASLCAQ HGTCGGFHAT
PAAAAAPSTS AGSDAVSPSI TPTTATHEIY SGLFRESFVN PFNGRLVRTT SSAAKMLFGV
GFYRGVSNPL QIEWSPAEYM VALQKIMSTQ QRNAARRRER QAQQALRGAK AAAAAERGSS
ASATKKARAD GSRARSSAKC RVSEAAPMPA AEAVAQARSQ LLRPFLRRGP DHWTASVAKL
LERHDAFTYV NKELGQLYAR LRGAYMPPKL DTPADPCTMG MTLTPDQHHV VKLALRGFNL
FIGGSAGTGK TVLLKCIYRE LCQMGLRVAM TATTGVAAVQ LGGCTFHHAF NAPLLDTAPH
RWDANALRAV DAVIIDEVSL LDACMLDAFD MEARLARMHH RPFGGLQLIV CGDFLQLSRE
DTLPAYESAA FKHLVALRLV TPMRHAADDP LMKLLEDLRR GRFDAERFAA LDRPIPPNTT
HITYLFPRRR EAQQLNDLKL GELMTQEMIF TPQRGPLQLC GSFTHSALVE LNRDANGMRA
AMPNRERLLE MIHEEAQRLR AGLHRKDGGG REPVPSVADH ELVLMPVRAE GALETRFILR
LRCRERELHK PKTRDGGDDD ADSGDDGAST RSSSLAADGA PALMAGRTHS STLAAVAAET
LRKPVISLAT KRTRRATAPF SATEWEGIAT AVATRLGGRV VTMLEEEPSS MVPLSVTMTL
ADMTSSDVAL SLTPLRLKLG CRVMVNRNLS RTVSNGSVGV VEAFAPPDVS LFPRRTDRAA
RVIFQRVCQQ RLFAQLPVVR LLGGEVVQIP PISIVLGGTA QSYFYGHEVL TIPLQLGYAF
TVHKVQGLTL QGTVVLDCEK FFDCAHLIYV ACSRVRKLDQ LVVYRVQPNM IIVRRSALEF
SDQLQDARNS KVLISPPPAA RSSWSRHTEQ RVFAVSA
//
