ID A4I4G0_LEIIN Unreviewed; 350 AA.
AC A4I4G0; A0A2K4YZG7; A0A381MMX2;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Enoyl reductase (ER) domain-containing protein {ECO:0000259|SMART:SM00829};
GN ORFNames=LINJ_29_1100 {ECO:0000313|EMBL:CAM69669.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM69669.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM69669.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM69669.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM69669.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM69669.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796461; CAM69669.1; -; Genomic_DNA.
DR RefSeq; XP_001466629.1; XM_001466592.1.
DR AlphaFoldDB; A4I4G0; -.
DR SMR; A4I4G0; -.
DR STRING; 5671.A4I4G0; -.
DR GeneID; 5070662; -.
DR KEGG; lif:LINJ_29_1100; -.
DR VEuPathDB; TriTrypDB:LINF_290016000; -.
DR eggNOG; KOG1198; Eukaryota.
DR InParanoid; A4I4G0; -.
DR OMA; WAEVPDP; -.
DR OrthoDB; 2598390at2759; -.
DR Proteomes; UP000008153; Chromosome 29.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd05276; p53_inducible_oxidoreductase; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR014189; Quinone_OxRdtase_PIG3.
DR NCBIfam; TIGR02824; quinone_pig3; 1.
DR PANTHER; PTHR48106:SF8; QUINONE OXIDOREDUCTASE PIG3; 1.
DR PANTHER; PTHR48106; QUINONE OXIDOREDUCTASE PIG3-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
FT DOMAIN 13..331
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 350 AA; 37716 MW; 3EDDE27D2220AC31 CRC64;
MQLMRAVTLK GFGDTDMLQI SRIPKAAITR GRDILIKVSA AGVNRADAAQ RKGHYPPPKG
SSEVLGLEVS GIVEQVGDDV KDFKEGDKVM ALLPGGGYAE YAVAHEGSVM HIPQGYSFIE
AAAIPEAFLT AWQALKYHGD CRRGQKVLIH AGASGVGTAA AQLVEKYFQA TALTTSSESK
VEVCKNFASI NLTRTPDETG MCFSPKVKSL LGEGAINLVL DSVFGGSYIS EDAAVLAKDG
RIVVLAFMGG ATVHLNCLPL LRQRAHVMFS KLRCQSDDYK QNLVDTFEEA VIPYMNERLI
VPVANKTYPL EEVAQAHARL DDRKAWGKIV LTFNSHLSAT SANPLPTPKA
//
