ID A4I4L8_LEIIN Unreviewed; 353 AA.
AC A4I4L8; A0A2K4YZI9; A0A381MN46;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Putative glutamamyl carboxypeptidase {ECO:0000313|EMBL:CAM69730.1};
DE EC=3.4.-.- {ECO:0000313|EMBL:CAM69730.1};
GN ORFNames=LINJ_29_1680 {ECO:0000313|EMBL:CAM69730.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM69730.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM69730.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM69730.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM69730.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM69730.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR EMBL; FR796461; CAM69730.1; -; Genomic_DNA.
DR RefSeq; XP_001466687.1; XM_001466650.1.
DR AlphaFoldDB; A4I4L8; -.
DR SMR; A4I4L8; -.
DR STRING; 5671.A4I4L8; -.
DR GeneID; 5070723; -.
DR KEGG; lif:LINJ_29_1680; -.
DR VEuPathDB; TriTrypDB:LINF_290022300; -.
DR eggNOG; KOG2275; Eukaryota.
DR InParanoid; A4I4L8; -.
DR OMA; FYTEASH; -.
DR OrthoDB; 158507at2759; -.
DR Proteomes; UP000008153; Chromosome 29.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd03894; M20_ArgE; 1.
DR Gene3D; 3.30.70.360; -; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR036264; Bact_exopeptidase_dim_dom.
DR InterPro; IPR002933; Peptidase_M20.
DR InterPro; IPR011650; Peptidase_M20_dimer.
DR PANTHER; PTHR43808; ACETYLORNITHINE DEACETYLASE; 1.
DR PANTHER; PTHR43808:SF8; M20_DIMER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07687; M20_dimer; 1.
DR Pfam; PF01546; Peptidase_M20; 1.
DR SUPFAM; SSF55031; Bacterial exopeptidase dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000313|EMBL:CAM69730.1};
KW Hydrolase {ECO:0000313|EMBL:CAM69730.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protease {ECO:0000313|EMBL:CAM69730.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
FT DOMAIN 176..288
FT /note="Peptidase M20 dimerisation"
FT /evidence="ECO:0000259|Pfam:PF07687"
SQ SEQUENCE 353 AA; 39015 MW; 22A10A48A32E7B34 CRC64;
MSYPATFREW LAKIISFDTT SRNSNLPMVE YVRDYLRSVG VASTFVYNPE KTHANLWATL
PGENGAMQGG IVLSGHTDVV PVDGQKWDSD PFTMVEKDGK LFGRGACDMK GFLAVVLALT
PQFLRMNRVK PVHYAFSFDE EVGCTGVPYL IEYLKAHGFL ADACLIGEPT DMNVYVGSKG
FTQWSVSVQG KAIHSSMALM NTSCNAIEYA AQIITKVREI AVDLRKNGRQ DPEYACPFPC
ITTGLIKGGN AVNTVPAQCE FVVTARITDN ETPDAIERRV RSYVNDHVLP AMREEYPDAE
VKVTRPLSMP AFNGKEAASV TQKALMLRKA TRTYKTGGST EGGYFEDVWV SQR
//