ID   A4I4S9_LEIIN            Unreviewed;       700 AA.
AC   A4I4S9; A0A2K4YZQ7; A0A381MN32;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 98.
DE   SubName: Full=Putative GTP-binding protein {ECO:0000313|EMBL:CAM69795.1};
GN   ORFNames=LINJ_29_2310 {ECO:0000313|EMBL:CAM69795.1};
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM69795.1, ECO:0000313|Proteomes:UP000008153};
RN   [1] {ECO:0000313|EMBL:CAM69795.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM69795.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM69795.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM69795.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
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DR   EMBL; FR796461; CAM69795.1; -; Genomic_DNA.
DR   RefSeq; XP_001466748.1; XM_001466711.1.
DR   AlphaFoldDB; A4I4S9; -.
DR   SMR; A4I4S9; -.
DR   STRING; 5671.A4I4S9; -.
DR   GeneID; 5070788; -.
DR   KEGG; lif:LINJ_29_2310; -.
DR   VEuPathDB; TriTrypDB:LINF_290029700; -.
DR   eggNOG; KOG0446; Eukaryota.
DR   InParanoid; A4I4S9; -.
DR   OMA; KICHNCG; -.
DR   OrthoDB; 1052588at2759; -.
DR   Proteomes; UP000008153; Chromosome 29.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd08771; DLP_1; 1.
DR   Gene3D; 1.20.120.1240; Dynamin, middle domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR022812; Dynamin.
DR   InterPro; IPR001401; Dynamin_GTPase.
DR   InterPro; IPR019762; Dynamin_GTPase_CS.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR000375; Dynamin_stalk.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR003130; GED.
DR   InterPro; IPR020850; GED_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11566; DYNAMIN; 1.
DR   PANTHER; PTHR11566:SF21; DYNAMIN-1-LIKE PROTEIN; 1.
DR   Pfam; PF01031; Dynamin_M; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF02212; GED; 1.
DR   PRINTS; PR00195; DYNAMIN.
DR   SMART; SM00053; DYNc; 1.
DR   SMART; SM00302; GED; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00410; G_DYNAMIN_1; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
DR   PROSITE; PS51388; GED; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|RuleBase:RU003932};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU003932};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008153}.
SQ   SEQUENCE   700 AA;  77988 MW;  E5710BC8521D682C CRC64;
     MDQLISVINE LHDAFAGVKM NIKLNLPQIA VVGSQSCGKS SVLESIVGKD FLPRGSGIVT
     RCPLVLQLVQ LPKSNEEEWG EFLHIPNKKF YDFNEIQNEI TRRTIEMAGP SAITDKPISL
     KVYSNTVLNL TLVDLPGLVM NAVGDQPKDI DRQIKDMVTR YVSPKNTIIL AISPANTDLA
     TSQSLRLAKQ LDPEGVRTVG VLTKIDLMDK GTDCFDVLQN KVLQLRHGFV GVVCRSQQDI
     NDRKSMEAAR RSEYEFFANS PIYSPIAEEA GTAYLSKKLN FLLLEHIKAV IPDLKRHVDQ
     LMEATKKQME KLGMFEQDIT EPTAQLLYLI KLFSDTLNQT IDGGITDATK ELLGGARLDY
     IFHECFATYV TSLSATKDLT DDYIRINTRN MAGMHATLFP SDQVFVALSK QQITRLEEPC
     IKCVTFVYEE LTKIVEICAG KVDRYPNLKD AIISICKKML LDYRLPTSTH VRTIIKAERG
     FINVKHPMMD ELAQRAFANI YGTTNGDASS PPRNSSDPNA SAAGGTQADP KQSGRDIKRD
     DRKDDKRGGR DEKRPEKSRD QGNADNVMSP GSKSDMNDVP SRIMLGKNMT MHEQYMNSAI
     REMVEGYFSI VKGNVADQVP KAITLLMITR LREEVYARLV SELYSDKTAK ALLSEPPGIA
     TQRKAAKEML EALTKAQNAL NSVRDYQLTK EPSSSMQAGA
//