ID A4I500_LEIIN Unreviewed; 762 AA.
AC A4I500; A0A2K4YZX2; A0A381MNT1;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CAM69868.1};
GN ORFNames=LINJ_30_0050 {ECO:0000313|EMBL:CAM69868.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM69868.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM69868.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM69868.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM69868.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM69868.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796462; CAM69868.1; -; Genomic_DNA.
DR RefSeq; XP_001466819.1; XM_001466782.1.
DR AlphaFoldDB; A4I500; -.
DR SMR; A4I500; -.
DR STRING; 5671.A4I500; -.
DR GeneID; 5070861; -.
DR KEGG; lif:LINJ_30_0050; -.
DR VEuPathDB; TriTrypDB:LINF_300005500; -.
DR eggNOG; KOG1863; Eukaryota.
DR InParanoid; A4I500; -.
DR OMA; CEFIVFA; -.
DR OrthoDB; 160321at2759; -.
DR Proteomes; UP000008153; Chromosome 30.
DR CDD; cd00121; MATH; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR008974; TRAF-like.
DR PANTHER; PTHR46236:SF35; TRAF-LIKE FAMILY PROTEIN-RELATED; 1.
DR PANTHER; PTHR46236; TRAF-LIKE SUPERFAMILY PROTEIN; 1.
DR Pfam; PF00917; MATH; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50144; MATH; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
FT REGION 105..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 727..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..119
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 762 AA; 86996 MW; EF44711473216588 CRC64;
MHRLSSLSEG DLCFYQSTLY QLIQDAPIEA KPGREMMRTL RKELVRSMEQ EECPEYCAAL
ADLYKTVTDT LISAAHRSAP HELINRTTSD CRIVTDEDEY QFHQEEGFFD DEDEDEMDSN
SDIKSTAKDA EQKQRKREET KRKRREEEDM LMKERKVTDE KGKQYHTLGP FPPPRLTVRA
PTNTFPSRKA LQQRTIIETP SSTSSSSDDD EAINQLISSR STEGGEAVNH LTDFLQPLSI
DSLKKVGESA KAKLRPSSTH DEFVSQIVKT AVRLGCEKAC VLMEKQKIIE DMTSHVQTGP
LPTAASIDFL NTLPDHLKQS LGSVLGLPEE KPPVEDMWER MVAMGFLSVL TNLRLKPLKK
IANELSIVLP DTNSTEKFCE FIVFAAFPRE RIRAKFSRAK QKKVKFTVPP DSMSIKGDMG
FVTFHVNNIS MLTKESERHY SPEFHFANLK WSLLCMTNKE SLALYLCQTG SVHCKFLITV
VNKANPDDSI CNEGTQSFSA MSQENDWGFN NVIKFAELLN PDQGFVTADD DSITIEVGIV
LVEPLKTPTA REKAPVAKEK KNEPRVDEAA MLQLLADEKV EQTRKKLKQE ISKTIREEEK
TRKDITQRAS KAYHDLCDRL RQETKRTQKE VADRERKEEQ ERQRELDKIK QAQEQTAELK
SRLQSLKKEN AELIQSKQDA TQAAKEAKKN SERIVQELKF VLDRVQSTQQ KLHTQEKKLA
AAKSRYESIL AEEPDTPSPS DDENDLMSED LTRFINLMTE DM
//
