ID A4I861_LEIIN Unreviewed; 650 AA.
AC A4I861; A0A2K4Z2T7; A0A381MR55;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Nucleoporin NSP1-like C-terminal domain-containing protein {ECO:0000259|Pfam:PF05064};
GN ORFNames=LINJ_32_2530 {ECO:0000313|EMBL:CAM71001.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM71001.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM71001.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM71001.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM71001.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM71001.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the nucleoporin NSP1/NUP62 family.
CC {ECO:0000256|ARBA:ARBA00005911}.
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DR EMBL; FR796464; CAM71001.1; -; Genomic_DNA.
DR RefSeq; XP_001467930.1; XM_001467893.1.
DR AlphaFoldDB; A4I861; -.
DR STRING; 5671.A4I861; -.
DR GeneID; 5071993; -.
DR KEGG; lif:LINJ_32_2530; -.
DR VEuPathDB; TriTrypDB:LINF_320029900; -.
DR eggNOG; ENOG502S02M; Eukaryota.
DR InParanoid; A4I861; -.
DR OMA; EMMSKQV; -.
DR OrthoDB; 157603at2759; -.
DR Proteomes; UP000008153; Chromosome 32.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IEA:InterPro.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR026010; NSP1/NUP62.
DR InterPro; IPR007758; Nucleoporin_NSP1_C.
DR PANTHER; PTHR12084:SF0; NUCLEAR PORE GLYCOPROTEIN P62; 1.
DR PANTHER; PTHR12084; NUCLEAR PORE GLYCOPROTEIN P62-RELATED; 1.
DR Pfam; PF05064; Nsp1_C; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000008153};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 453..552
FT /note="Nucleoporin NSP1-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05064"
FT REGION 95..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 650 AA; 61241 MW; F4B8F25A1B4813F2 CRC64;
MAFNAFASST APGFGAASTP AGVCGFGHAG GAAPAAPTGA GGFNAAPASA PASGLSFGSG
TSAPAAATPT PTASTVGFGG FIAGHAASTS VTAASGFSTA PQPPASTPTP FSGSGFGPGA
AAPAAASATA APAASTPFAA ASIPAAPVSG GGGFGGTTSS AAATPFSGFG TNTGATLAAP
VGAAPATAPA SASPASGAFN FATASVASAS AAKAPTNFGP FGGAAAAATP APVALTASAE
GAKAPSNALF GPNSGNSAPS AGLPVGGTGT SGLAAASAGF GDKSASSAPA SGAAGGGFNF
AGAATTAPAT GGGFHLGSAA SALAAPTVNK TPAPAAAAAS GGFSFGGATP SPAAGPAAAS
AAGGFGVTSA TPAPAAAPAA APSTSGGFTF GGTGAAAASS DATTAAGATV PSAVTGSPPA
AATGASTTPI TADATSSAKR AENAPPLPTA AATAASPSQE FDGKSLAAVL RKLDVDISLD
QRHFADLARH VVARDRQIMA RGRELAEVQS VVKDALTAAK SAEATLAECK QRQTALSEYL
QSLEDKIQPY YAQWEQLQQQ VHSADPCSVD QQRAVTYDNV MALLEEVQGV EEKVGRAVRQ
HNHSRDELLG LSEIEGAMRL IDGQLCALQC CSALASALEL ELDRLLGKAS
//
