ID   A4IC28_LEIIN            Unreviewed;       725 AA.
AC   A4IC28; A0A2K4Z753; A0A381MVQ5;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 82.
DE   SubName: Full=Putative tubulin tyrosine ligase {ECO:0000313|EMBL:CAM72403.1};
DE            EC=6.3.2.25 {ECO:0000313|EMBL:CAM72403.1};
GN   ORFNames=LINJ_35_4980 {ECO:0000313|EMBL:CAM72403.1};
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM72403.1, ECO:0000313|Proteomes:UP000008153};
RN   [1] {ECO:0000313|EMBL:CAM72403.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM72403.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM72403.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM72403.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
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DR   EMBL; FR796467; CAM72403.1; -; Genomic_DNA.
DR   RefSeq; XP_001469297.1; XM_001469260.1.
DR   AlphaFoldDB; A4IC28; -.
DR   SMR; A4IC28; -.
DR   GeneID; 5073395; -.
DR   KEGG; lif:LINJ_35_4980; -.
DR   VEuPathDB; TriTrypDB:LINF_350054800; -.
DR   eggNOG; KOG2156; Eukaryota.
DR   InParanoid; A4IC28; -.
DR   OMA; FNILWAK; -.
DR   OrthoDB; 7265at2759; -.
DR   Proteomes; UP000008153; Chromosome 35.
DR   GO; GO:0004835; F:tubulin-tyrosine ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR   InterPro; IPR004344; TTL/TTLL_fam.
DR   PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR   PANTHER; PTHR12241:SF160; TYROSINE LIGASE PROTEIN, PUTATIVE-RELATED; 1.
DR   Pfam; PF03133; TTL; 1.
DR   SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR   PROSITE; PS51221; TTL; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:CAM72403.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008153}.
SQ   SEQUENCE   725 AA;  81051 MW;  701A5E1A9B61C366 CRC64;
     MSASANAFPA LSGGFKLPSV TAAPKNAVAR MPSRVVHQAR SLPSVTRDLV APTPSSTPSL
     YPQSLWWDAQ QGKEDTDKIT RRRTYRVSDY PPIIVGKYVT DPTGKDFSNP HYVPAGTAAR
     SRSSSRAAAR SGASVTALSR VSSSATTCST CTTTSSTVRG PEEDEENLAL RVTAKRKLFT
     VVMPVYPSSA ASFFFPTAYV QSSRDAADWR GPPKKINEDL HPNDRANFSL SYVSVRENNL
     NRMGLYKIGP GAVAFSAVIK AFEAGGLRYT DSNKDFNILW AKRATVYTLS SLNAYQKVNH
     FPGTWGVGRK DRLAYNIRRM QRHFGDDAFD IVPKSFLIPQ DEAELRRDAE IDPGTPQKPL
     IYILKPGASS CGRGIHLFKG VPPMPRGAGR EKEMVCQRYI GNPLLIYGRK FDLRLYCVVT
     SFDPLRIYLF DEGLVRFAAK KYSGPDQDLD NIHVHLTNYS VNKTAELSKE SNGKDYESDD
     PLDIKWCLSD FKRHLASHHP LGLAAWDRIQ AECEDVVIKT FLSIEHNVME EVTRNCADRS
     GRNCFELFGL DLMADDNLKV RLLEVNIMPS LATGSSLDKA VKSRMLSHML TLVRVIPYRR
     DSQLDPNNTD GIYVPRGIQR QAGERTYKFG NHPFPSARIV ERPLLTAFND PGNEDSYLSM
     AESLMLREYE EELQCAGGFR CIYPVGRTVD RYLPYFLHGV RRSNYLLASA AVMKSKQPPN
     EKLFD
//