ID A4ICN9_LEIIN Unreviewed; 4172 AA.
AC A4ICN9; A0A2K4Z7S7; A0A381MVY1;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=Putative dynein heavy chain {ECO:0000313|EMBL:CAM72617.1};
GN ORFNames=LINJ_36_1010 {ECO:0000313|EMBL:CAM72617.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM72617.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM72617.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM72617.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM72617.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM72617.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796468; CAM72617.1; -; Genomic_DNA.
DR RefSeq; XP_001469508.1; XM_001469471.1.
DR STRING; 5671.A4ICN9; -.
DR GeneID; 5073609; -.
DR KEGG; lif:LINJ_36_1010; -.
DR VEuPathDB; TriTrypDB:LINF_360015300; -.
DR eggNOG; KOG3595; Eukaryota.
DR InParanoid; A4ICN9; -.
DR OMA; HNVAKMV; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000008153; Chromosome 36.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
FT DOMAIN 1473..1610
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2101..2251
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 522..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2763..2826
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2949..3011
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4172 AA; 473298 MW; 63DAB4DC75CC7649 CRC64;
MATNLSVRGE VSRAELLQRK RQRIDTGPTL SELLIARGMH AAAASDLVGN PEDGSAGIAP
CAAAGDYATW LPVEAFDDAF RFEELSPEDW AARVAAAPSG LPCVFWKLDH RQHHKGGIWT
SGRVVEVDVD KQLYYVLPDD GRDLRSSQKQ KADTCGSAED TRPLALPRVF VCFAAEDPEN
FANRFAAAHK RRTIAEAALR TELYVDFIPL DEYAALDPLV IRRVLDAAVS TPALVECESN
LNVAGVLEEV RAGYSRVMNA DLFHSITQGG GLSQLTGPSA TSSTMLSASP LFMSGTARPV
PLYGVSSHQA ERFTATVAAF RQQCFWNTSP ALAALTRAVC RADDALLSRC VFVLYSTTKM
KRPLSLMELE EIETTATRDS FLHARDQWLT PTADMVKRTL STFSSTDPVH LHHYDVNTYA
GCSTERYLRQ IQLHMQDTLQ HYLISSLEAL IRFVEHAGDN HVTVHGMAQV EVTRGAHPAP
RTPFGADERI TAGFLLPPPH PLPPLLSVVL LCTKRVSDAG AKAAQEALET PATETQAPKP
VAGDLPEEDE GSAKTEKPSA ACLSYSCSVE SIRVSLQGLL KRCLTQHSTL RTVERVLFDF
LYDPATAFLN VPAASSMLME SWVQRINVVL DRVAVAMKSY RETYTPFTAV IELDLNAYMA
TFDERFPSTR GVEAEVQRFL TLQQQVLDGI PVSADLGLVR VDCSELRREL SKKCAMGAAK
VLDVMAARAL RKEIEVTDRY SELYATLLKP TETPEEVVAT KDFIKTIPER VVDLETAIEE
SKEIHELLKG FKRPLSEEEF NKKWKAIGWP SQLDNAVNER VEELEETKRR LLASMNRAQD
LFEQEVERIQ KIVEHYGQHR NAHRMTEIAE DVMRVQEKIR QLRSQASTFN THESLFNMEK
TDYSAVHQLA TDFEPYEALW ITSASWSASL KKWHELPFMS IDADEVERVV ADTLRIMNTC
VRNPQLRPEL VQVAEHTREN VQQFRPLVPT IKYLRMEGMH ERHWSQLSKE LGQAIEPAVT
LQSLDDVVRM NLTQQNDVLM RISEIASREF HIETSLAKMK AGWADMRMSV TAYKETGCLV
ISKDVVDQTQ EKLDDQMLLT QSLSFSPFKQ LFEDEIANWE TSLKLVQDVL DAWLRCQKSW
LYLEPIFQSE DISRQLPGEY KRFQVVNKNW KFLTNKAQEV DLTLEFCTTT ERCLELLKEN
NDTLEVVERG LNQYLENKRA SFARFYFLSD DELLAILSEA RDPQRIQPQF RKLFENIARI
DMRNADNEMF GMYSQMEEYI PFAQSVLPRK YVENWLTEIE HMMKISIRLQ LEAGVKNAAT
MKRQAFVLQS PGQVAIAVNQ IMWTHECEMS LKEQGSLAPY MATAQRNLMV LVETVRLPLT
NLQRMNLSGL ITIEVHARDI VEQLAKAGVD SIYAFEWVSQ LRSYWENSDC VLRQVEAQFR
YGGEYLGNTT RLVITPLTDR IYLTLTGAMH MFLGGAPAGP AGTGKTETVK DLAKAVAKQC
VVFNCQEGMT YASMAKFFKG LAQAGAWACF DEFNRIDVEV LSVVAQQVSS LQEAARTRQF
RIPFEGTEIV VDPSYSVFIT MNPGYAGRTE LPDNLKVLFR PVACMVPDYA MIAEIRLFSF
GYSDSRKLAQ KMVATFRLSS EQLSSQDHYD FGMRAVNTVI SAAGLMKREH PDEAEDVLLL
RALRDSNAPK FLEEDLLLFD GITSDLFPGV ELIPAGYGDF LAALEAKASS MRLQPTEMFV
KKCVQLYEMS VLRHGQMAVG PTMGGKTSAT RVLQAAMTHL RKELKSTKFA EVKTYCLNPK
SIMMAQLYGG FDEATGEWRD GIIGEVFRLA ARDTTDARQW IIFDGPVDAL WIESMNTVLD
DNKKLCLISG EIIAMTPYMN CWFEVEDLAV ASPATVSRAG MIYLEPNTCV GVRNFILSWQ
QYRLPVTMDP YKEYLQELCE QLFPSLIHFV QTEVTEYSPS TWPNLVVSCF NLFDCFMSPY
TPTRTYEVPQ DKLDLLREIH LHLLIFSVVW SFGATGDRPS RQRFDKFLRD ELRLRNVNIE
LPVIGCLQDY QFIPEERRWI AWAERLPPFT TQVTQSNFSD IIVLTADVAR YKYVNRILLE
HSYHTLCCGP TGTGKTVLMR QLLMHEMPKE CTPIFFTFSA RTSANQTQDL IFSKLEVRKR
ASPQVWGAPL NRKFIILVDD MNMPLKEQYG AQPPIELLRQ FMDYKGWYDR RTREFFSIVD
VVLAGTMGPP GGGRHFITQR FLRHFHQIAF PEIEDDSMSR IFLSLLESYF SLFAEDVRGK
LSAVVMASIE VFNTAVKELK PTPARPHYLF NLRDLAKVMD GLTNATPATV KTVPELVRLW
LHEEMRTFQD RLTNDADRAW FQELLGKQLH KHLKLSMNDV TQRHRGDGCA AADSKNPQTP
AADMNTLMFV DFMGGKSEQR IYQEAADFDA VVKTLEQQLR DYNQQCIGGR QLDLVMFADA
AQHVCRIARV LRKPNGHALL LGVGGSGRQS LSRLAAHLNE YELFQVEIAK GYTMNAWRED
VKAVLQRVAL QKKQVLFLFA DTQIVHEAML EDVNNLLNSG EVPNLFVGQE LEDLLNSMRH
VCVAEGLPVD KVTIFARFVR SCRSQLHISL CMSPLGEVFR SRLRMFPALV NCCTVDWFSA
WPQQALRSVA RNYFAMVPLL AQQAKAVEAC TEVCVRIHVS VDAVSVRFLA ETQRHNYVTP
TSFLELLHTF RALMETQTEK NQTTKDRFIN GLAKLRETED AVAELQQTLS QSQPALLEKN
ESIRALVAEM ELQTTEAEKT KKEAQKEREA VATMQAECAA IEGAAQEQLA EALPELDRAL
ESLKNLKSSQ ITEVAGYKAP TAGVVMTMQG ICILFQIRPQ MRAASLMEKK PDFWATAKEQ
LLNNPNLLLQ RLIQYDKENI PEKLIQAVMP LVTSDDFTPK KIAGASQACA AMCQWTHAMV
RFHEVNKKVA PLRQELAVAQ QANQKAQQKL KEAETQLADV AERLADMQRR KEEAERELEE
LGQTVKRTAL RLERAAMLID GLAGEKRSWM QSLERIDESA QYLMGDMLVA AGQIAYCGPF
TSVYREELLE SWGKELDQRS ILHSAQYSIY HTLQDAVETR EWILKGLPMD TLSIENALFA
KSARRWPLLI DPQTQGNRWI RRTYKDSLEV VRPSQKDLVK RIEYCIRAGR PVLLENIGED
IDASLNPLLE RRTFMEGGTE MLRISDTPIP WNPKFKFFMT TKLPNPHYIP EVMVRVTLLN
FFITPRGLED QLLGVVVGQE RRELEMRRSD LIQKNAAMKA DLINTQESIL CKLKEVQGDV
LDDVELIAYL NESKEKTLEI TTRVAEAEAA EVELTASREE YRPIAHHSSC LYFCCSTLSN
VDPMYQYSLQ WFVQLFIASI EQARRADDVA QRLENLKEYF TYSFYQNVSR SLFEKHKLMF
SVYLCVRLMD QRGQVDAAEF RFLLQGPTLV ADAKDNPDPS WITPATWNEW CYLDQNFGPF
KGLKAHLCAH LSHYKELFMS SAAHRQPMAA DWADKLTPMQ HLMFLRCVRP DKLMERLQDF
VLAEMGEKFI RPPPFDLLTS FKDSGPAAPL IFILSQGADP YDDWKRFADA QNMSKKLYDV
SLGQGQGPRA ERMVQEGMEN GSWVLLQNCH LATSWMPTLE RLVEAITPNT HPSFRLWLTS
MPNAHFPVAV LQNGVKMTNE PPKGLQANVS RSIGAYSGEF LESCQKSVEL KKLFFSMCFF
HALLQERRKF GPLGWNIAYE FTSGDLGCCA AQIKMFLDKY AEVPYTVIRE LSGNIHYGGR
VTDEWDRRTL NTLLERFVTP DVMADGYLFC PRLEEYQSIP VTNRQGYLDY VASWPLNTNP
ETFGLHENAD ITCARTETFE TLQAIVLLHG DEGRRGDGVP SSSAAASTPD DMVKTFAEAI
HRKVAAPFDV DQFRRKYPTK YEDSMNTVLV QEAIRFNRLV TLLHQTLEQL PMAIRGEMVM
SKELEEVYLA LYNNQVPALW SDKAYPSLKS LGAWVDDLVR RLAMVQNWYA NGHPKAYWIS
GFFFPQAFLT SVLQNYARTL HISIDTISYE FEWMSTDPAS VTTPPEVGCY IHGMFIEGAR
FDPATLTLAE SLPKVLYEQA PLLWLKPVVN RLSPASGIYE CPLYKTVRRA GTLSTTGHST
NYVLAVEVRT PPKADAKHWI RRGVALVCAL SV
//
