ID A4ID03_LEIIN Unreviewed; 1451 AA.
AC A4ID03; A0A2K4Z8H6; A0A381MX16;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Telomerase reverse transcriptase {ECO:0000256|ARBA:ARBA00016182, ECO:0000256|RuleBase:RU365061};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493, ECO:0000256|RuleBase:RU365061};
DE AltName: Full=Telomerase catalytic subunit {ECO:0000256|RuleBase:RU365061};
GN ORFNames=LINJ_36_4120 {ECO:0000313|EMBL:CAM72732.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM72732.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM72732.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM72732.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM72732.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM72732.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the
CC replication of chromosome termini in most eukaryotes. It elongates
CC telomeres. It is a reverse transcriptase that adds simple sequence
CC repeats to chromosome ends by copying a template sequence within the
CC RNA component of the enzyme. {ECO:0000256|RuleBase:RU365061}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.49;
CC Evidence={ECO:0000256|ARBA:ARBA00024557,
CC ECO:0000256|RuleBase:RU365061};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365061}.
CC Chromosome, telomere {ECO:0000256|RuleBase:RU365061}.
CC -!- SIMILARITY: Belongs to the reverse transcriptase family. Telomerase
CC subfamily. {ECO:0000256|ARBA:ARBA00008001,
CC ECO:0000256|RuleBase:RU365061}.
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DR EMBL; FR796468; CAM72732.1; -; Genomic_DNA.
DR RefSeq; XP_001469622.1; XM_001469585.1.
DR AlphaFoldDB; A4ID03; -.
DR STRING; 5671.A4ID03; -.
DR GeneID; 5073724; -.
DR KEGG; lif:LINJ_36_4120; -.
DR VEuPathDB; TriTrypDB:LINF_360048200; -.
DR eggNOG; KOG1005; Eukaryota.
DR InParanoid; A4ID03; -.
DR OMA; NLSHQDE; -.
DR OrthoDB; 127986at2759; -.
DR Proteomes; UP000008153; Chromosome 36.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003721; F:telomerase RNA reverse transcriptase activity; IEA:InterPro.
DR CDD; cd01648; TERT; 1.
DR Gene3D; 1.10.132.70; -; 1.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR021891; Telomerase_RBD.
DR InterPro; IPR003545; Telomerase_RT.
DR PANTHER; PTHR12066; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR PANTHER; PTHR12066:SF0; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR Pfam; PF12009; Telomerase_RBD; 1.
DR SMART; SM00975; Telomerase_RBD; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU365061};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU365061};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU365061};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU365061};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365061};
KW Reference proteome {ECO:0000313|Proteomes:UP000008153};
KW RNA-directed DNA polymerase {ECO:0000256|RuleBase:RU365061,
KW ECO:0000313|EMBL:CAM72732.1};
KW Telomere {ECO:0000256|ARBA:ARBA00022895, ECO:0000256|RuleBase:RU365061};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365061}.
SQ SEQUENCE 1451 AA; 157577 MW; 42F91AAC815EB340 CRC64;
MSASFPSIPG FAGPLSLKAF LEEYFGLHLT FAVETASPSP RAAAAAEAPS AAGFRALRDV
VLPPNQSFLV VVYVALHASS SPPPTTAHAS PTPPTPAPGC AASATGFGRL RQPLTHQTAA
STAHDTYVAR CSPADRPNSS CSSSSSTGKN GNARGLWRSS AFWLLYTNTS HRPLTDALLR
HPWWASFAAC LGPAAMGFIE MYCPIVLQLE AMAGGVQVLG PALKHAALET SFSATAPSSE
MKGPPPQGSG YVSSRGVKRA VDTGECSGFL PLQKQRRVEA PPKAKAGRRL QRGVVPCSRP
RRDDPFASPV NRAAMPVTWA AALTRTDVPR TRLYSVRVSD SDGAGDGSGG ALPLPAGFLE
AQWLRRHPHS LHRVLQAALP KRVAYGASAR RYSVGASERV TGCTSVEDIP MWHVAHVFRW
LVLQPPQSGA DASPTTPPKF DLPSYLRRLL STVVDQCSRL DLRGAALKHT GYLEEAFRRQ
QQGVEPWDVQ RLSTPVDVVV SYLRTLLSTL RWAPLKEAKN RSFWGRDAAG SERVLDALMG
AVRNWLIAGR HAIVPVSRFL DGVPVAQVPW LNGFYTTTPS LPFSAATSSA ARHARRERSH
VQQRVWLQFV LFLTQDILPF LLRASFTITW SSKNTHKLLF FPAFVWRRLI RREVRRTRSC
GAPRSQMPLA GESARSVGAE RVALSSAPCA CEGAATAALP TPHSAASKAS AAISAPRDVW
RAVRTDGVLA HRGARATLAT RGGGASCLYA SVRFRPDRRK LRPIAVVRSA SLRSLKEMAR
GSPSPYSHAS AIVRLLCRLG CSDTDGQLPA ATATLLRRVQ ARSRHNHHTG VHRFPHPLPP
HLPHKAALRD ALRCLVSGVE EQRVRDGLPR LSNLSHQDEY AELRSFCEEV RRRPALPCEG
PAGTAPVVSS ASPPSAAACC FAPYVTLVRS DASRCYDNLP QERVLAAVAS LVKHDAYRVL
RFTAIHALDG EAACKGGCLL RRTFTTRTIA CAEAECGVLA RIPRGHIYWE EEEEGRTLSG
PHTTAAVSRT TKASSRCGAN LISGAAVRAL LSEHLRHHLV VVSGGNLLEQ RVGILQGSPV
AMLLCDRLFS DVVDTALSGI LSEHAERSLL LRRVDDVLVA TTSPAAAERC LQAMQRGWPS
VGYLSNPSKL TLSTACGSLV PWCGLLLHDT TLEVSVEWRR IGVLLASLRV GDPHYVHRGD
HEPLYLTQRF LAVLQLRVAP TVLCGRMNSK TRQLQTFYEV GLLWSRVVLE KVQEALPAAR
NRCVAVLLLH PLAVCVGRLC RLLNRHQRFL AARKSACDVS AAEVRACVLT ALHRTVQAKL
RVLQARTVRV MTAQRGRTPR GTSLKGRQKP PCTNKASSAG CKYCERRRKG RNRRCSTRVC
LRSFWWLAAA EVELQWRRSL GALHRAAPHP GEARGSTAPS LSPSASASLL MEDGPLSMHA
RALSATRLSQ T
//
