ID A4IFA5_BOVIN Unreviewed; 673 AA.
AC A4IFA5; A0A8J8YKL2; G3N0B6; M5FK21;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 132.
DE SubName: Full=Slit-like 2 {ECO:0000313|EMBL:DAA15639.1};
DE SubName: Full=VASN protein {ECO:0000313|EMBL:AAI34481.1};
DE SubName: Full=Vasorin {ECO:0000313|Ensembl:ENSBTAP00000055273.2};
GN Name=VASN {ECO:0000313|EMBL:AAI34481.1,
GN ECO:0000313|Ensembl:ENSBTAP00000055273.2};
GN ORFNames=BOS_22534 {ECO:0000313|EMBL:DAA15639.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI34481.1};
RN [1] {ECO:0000313|EMBL:AAI34481.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=L1 Hereford {ECO:0000313|EMBL:AAI34481.1};
RC TISSUE=Ascending colon {ECO:0000313|EMBL:AAI34481.1};
RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA Holt R., Jones S.J., Marra M.A.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:DAA15639.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
RN [3] {ECO:0000313|Ensembl:ENSBTAP00000055273.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055273.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSBTAP00000055273.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055273.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; BC134480; AAI34481.1; -; mRNA.
DR EMBL; GJ062847; DAA15639.1; -; Genomic_DNA.
DR RefSeq; NP_001077265.1; NM_001083796.1.
DR STRING; 9913.ENSBTAP00000055273; -.
DR PaxDb; 9913-ENSBTAP00000055273; -.
DR Ensembl; ENSBTAT00000063699.2; ENSBTAP00000055273.2; ENSBTAG00000046339.2.
DR GeneID; 787995; -.
DR KEGG; bta:787995; -.
DR CTD; 114990; -.
DR VEuPathDB; HostDB:ENSBTAG00000046339; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000159318; -.
DR HOGENOM; CLU_432517_0_0_1; -.
DR OMA; GPWVRES; -.
DR OrthoDB; 5353685at2759; -.
DR TreeFam; TF351825; -.
DR Proteomes; UP000009136; Chromosome 25.
DR Bgee; ENSBTAG00000046339; Expressed in esophagus and 101 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0050431; F:transforming growth factor beta binding; IEA:Ensembl.
DR GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
DR GO; GO:0071461; P:cellular response to redox state; IEA:Ensembl.
DR GO; GO:0010719; P:negative regulation of epithelial to mesenchymal transition; IEA:Ensembl.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR PANTHER; PTHR24373:SF275; VASORIN; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF13855; LRR_8; 2.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00181; EGF; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..673
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035235830"
FT TRANSMEM 577..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 408..445
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 462..558
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 357..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..407
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 435..444
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 673 AA; 71707 MW; 49D4A529D7895E22 CRC64;
MHSRAPLRLL LPLLLLLPAL GPGVQGCPSG CQCNQPRTVF CTARRGTTVP LDVPPDTVGL
YIFENGITTL DAGSFAGLPG LQLLDLSQNQ IASLPGGVFQ PLANLSNLDL TANRLREITN
ETFRGLRRLE RLYLGKNRIR HIQPGAFDVF DRLLELKLQD NELRALPPLR LPRLLLLDLS
HNGLSALEPG VLDTANVETL RLAGLGLRHL DEGLFGRLRN LHNLDVADNQ LERVPPAVRG
LRGLTRLRLA GNTRIAQLWL EDLAGLAALQ ELDLSNLSLQ ALPHELSTLF PRLRLLEAAR
NPFNCVCPLS WFGPWVRESR LTLASPEETR CHFPPKNAGR LLLDLDYSDF GCPATTTTAT
APTTRAPVQE PTLPPSSLAP TQLRPTELAT EAPSQPPPAP PTAGPVPPPR DCPASICLNG
GTCHLGARGH LECLCPQGFT GLYCEGRVRP GPRPSPAPAT PRPLPLGIEP ASPTSLRVGL
QRFQQGSAVQ LKSLRLTYRN LSGPDKRPVT LRLPASLAEY TVTQLRPNAT YSICVRALGA
GRVPEGEEAC GEARTPPAVR SNHAPVTQAR EGNLPLLIAP ALAAVLLAVL AAVGAAFCVR
RGRAAAAVVQ GKGQVGPGAG PLELEGVKAP LEPDPKALEG GGEAPTGGLE CEVPLMGYSG
PGPQGPLPAK PYI
//
