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Database: UniProt
Entry: A4IHD2
LinkDB: A4IHD2
Original site: A4IHD2 
ID   ARIP4_XENTR             Reviewed;        1396 AA.
AC   A4IHD2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   31-JUL-2019, entry version 55.
DE   RecName: Full=Helicase ARIP4;
DE            EC=3.6.4.12;
DE   AltName: Full=Androgen receptor-interacting protein 4;
DE   AltName: Full=RAD54-like protein 2;
GN   Name=rad54l2; Synonyms=arip4;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA helicase that modulates androgen receptor (AR)-
CC       dependent transactivation in a promoter-dependent manner.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to be
CC       important for the association with nuclear receptors.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC       {ECO:0000305}.
DR   EMBL; BC135473; AAI35474.1; -; mRNA.
DR   RefSeq; NP_001076824.1; NM_001083355.1.
DR   STRING; 8364.ENSXETP00000000131; -.
DR   PaxDb; A4IHD2; -.
DR   PRIDE; A4IHD2; -.
DR   GeneID; 733747; -.
DR   KEGG; xtr:733747; -.
DR   CTD; 23132; -.
DR   Xenbase; XB-GENE-5829376; rad54l2.
DR   eggNOG; KOG1015; Eukaryota.
DR   eggNOG; COG0553; LUCA.
DR   InParanoid; A4IHD2; -.
DR   KO; K10876; -.
DR   OrthoDB; 815681at2759; -.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.10810; -; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038718; SNF2-like_sf.
DR   InterPro; IPR000330; SNF2_N.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF00176; SNF2_N; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; DNA-binding; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Repeat.
FT   CHAIN         1   1396       Helicase ARIP4.
FT                                /FTId=PRO_0000315783.
FT   DOMAIN      290    510       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      717    891       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     303    310       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       461    464       DEAH box.
FT   MOTIF       549    553       LXXLL motif 1.
FT   MOTIF      1273   1277       LXXLL motif 2.
FT   COMPBIAS     10     71       Glu-rich.
SQ   SEQUENCE   1396 AA;  156367 MW;  79566FD319FAA98B CRC64;
     MSDASISGSE PELDPEDMEE EEEDDEDDDE EEEEEEDEED NDGDDEDDKQ DINEKSQNAA
     LGEDSPEQGE EGWKRSTTSG QSGQESDEAK KKRLQKPANL RRNIRKLLRE DQLESVTKTA
     QQEELERRKR LEQQRKDYPL PLTLPPVSLD FLQEEIELRA ADVSQLVKSQ EIICLDSSSG
     ESDDEGKVKS HSIKDEIIEL SSGEEDNLQI SDNADSTNEV DGDITTENSG SHVNDALNQA
     DHLGRVLVNI NHPPNEKDIF LAPQLARAVK SHQIGGIRFL YDNLVESLER FSGSSGFGCI
     LAHSMGLGKT LQVISFLDVL FQHTSAKTVL AIVPVNTLQN WLAEFNMWLP PPESLPKDHN
     QELVQPRAFK VHTMNDEHKT TAARAKVVND WATDGGVLLM GYEMYRLLSL KKSFTAGRKK
     KSKKAAGPVI IDLDEEDRQQ EMLKGIEKAL SRPGPDVVIC DEGHRIKNCH ASTSQALKNI
     RSRRRVVLTG YPLQNNLIEY WCMVDFVRPD FLGTRQEFSN MFERPILNGQ CVDSTPQDKR
     LMRYRSHVLH SLLEGFVQRR GHTVLKAQLP FKEEHVILVR LSKIQRDLYT EFMNRFRDAG
     NSGWLGLNPL KAFCVCCKIW NHPDVLYEAL QKENLANEQD LDVEDLGTNN RCNAQSGKIK
     VEPNSLGALM GETAHTKQLQ GIVLNPSHEK ANQVVTYEWA KEILSDYIPG QLQNSPKMVL
     LFHLIEESMR MGDKILVFSQ SLSTLSIMEE FLAKRKMPIP AGSDGQEGHT WIRNVNYYRL
     DGSTSASERE RLINQFNDPS NEKVWLFLLS TRAGCLGVNL IGANRVVVFD ASWNPCHDAQ
     AVCRVYRYGQ RKPCYIYRLV SDFTLEKKIY DRQITKQGMS DRVVDDLNPE VNFTRREVEN
     LLHFVEEEPD ASRQHLDSSS FHEAVLQKAC LQYPHLITKE PFQHESLLLD RKEQKLTLAE
     KKAAKRGYEE EKRASVPYTR PSYTQYYPAP DHNLGNIPAF SQRHWRPLMK GDDRPVASVR
     PLQSTPIPML PRHVSVNHPG SASASVHPYN FPVNYLQRAG VLVQKVVTTT DIVIPGMTTS
     TDVQARISAG ESIHVIRGTK GTYIRTSDGR IFAIRASGKQ KSGEVRRQAT SGAQGSSAPY
     LSNGRHSTSS PSQQDSEDPP RPLSPDSPEI LNELQKYADA AAARGSHTAP QLQNLGLHHQ
     GINPAPKLQP RKRKDPQDQS SHWPSNKRNP YSQLSYPNTG GFGVTPSTMN HNLVRSSNPV
     FMGPGGGSSH FQLPSLLSDP QTGLPLVQDS LLTHSSGTSS APSVPPHYLL PRGFPLPFSQ
     SLLPQTRMFA PYPSQILNRG LPTNNPASTF PGYLSSHSNY QASPGTSSRP LPSGETELGS
     CEEDGRDDDV VEVTGE
//
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