ID A4IHF5_XENTR Unreviewed; 567 AA.
AC A4IHF5; F6YMZ2;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=GATOR complex protein NPRL3 {ECO:0000256|RuleBase:RU368069};
DE AltName: Full=Nitrogen permease regulator 3-like protein {ECO:0000256|RuleBase:RU368069};
GN Name=nprl3 {ECO:0000313|Ensembl:ENSXETP00000002483,
GN ECO:0000313|RefSeq:NP_001096273.1, ECO:0000313|RefSeq:XP_012825418.1,
GN ECO:0000313|RefSeq:XP_012825420.1,
GN ECO:0000313|Xenbase:XB-GENE-5818915};
GN Synonyms=c16orf35 {ECO:0000313|RefSeq:NP_001096273.1,
GN ECO:0000313|RefSeq:XP_012825418.1, ECO:0000313|RefSeq:XP_012825420.1},
GN cgthba {ECO:0000313|RefSeq:NP_001096273.1,
GN ECO:0000313|RefSeq:XP_012825418.1, ECO:0000313|RefSeq:XP_012825420.1},
GN hs-40 {ECO:0000313|RefSeq:NP_001096273.1,
GN ECO:0000313|RefSeq:XP_012825418.1, ECO:0000313|RefSeq:XP_012825420.1},
GN LOC100124838 {ECO:0000313|EMBL:AAI35505.1}, mare
GN {ECO:0000313|RefSeq:NP_001096273.1, ECO:0000313|RefSeq:XP_012825418.1,
GN ECO:0000313|RefSeq:XP_012825420.1}, npr3
GN {ECO:0000313|RefSeq:NP_001096273.1, ECO:0000313|RefSeq:XP_012825418.1,
GN ECO:0000313|RefSeq:XP_012825420.1}, rmd11
GN {ECO:0000313|RefSeq:NP_001096273.1, ECO:0000313|RefSeq:XP_012825418.1,
GN ECO:0000313|RefSeq:XP_012825420.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI35505.1};
RN [1] {ECO:0000313|RefSeq:NP_001096273.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000002483}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000002483};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [3] {ECO:0000313|EMBL:AAI35505.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole embryo {ECO:0000313|EMBL:AAI35505.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSXETP00000109655}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2021) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001096273.1, ECO:0000313|RefSeq:XP_012825418.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_012825418.1,
RC ECO:0000313|RefSeq:XP_012825420.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_012825418.1,
RC ECO:0000313|RefSeq:XP_012825420.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: As a component of the GATOR1 complex functions as an
CC inhibitor of the amino acid-sensing branch of the TORC1 pathway.
CC {ECO:0000256|RuleBase:RU368069}.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|RuleBase:RU368069}.
CC -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000256|ARBA:ARBA00010546,
CC ECO:0000256|RuleBase:RU368069}.
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DR EMBL; BC135504; AAI35505.1; -; mRNA.
DR RefSeq; NP_001096273.1; NM_001102803.1.
DR RefSeq; XP_012825418.1; XM_012969964.2.
DR RefSeq; XP_012825420.1; XM_012969966.3.
DR STRING; 8364.ENSXETP00000002483; -.
DR PaxDb; 8364-ENSXETP00000002483; -.
DR PaxDb; 8364-ENSXETP00000048072; -.
DR Ensembl; ENSXETT00000002483; ENSXETP00000002483; ENSXETG00000001136.
DR Ensembl; ENSXETT00000107088; ENSXETP00000115954; ENSXETG00000001136.
DR Ensembl; ENSXETT00000109764; ENSXETP00000118268; ENSXETG00000001136.
DR Ensembl; ENSXETT00000116109; ENSXETP00000111557; ENSXETG00000001136.
DR Ensembl; ENSXETT00000123814; ENSXETP00000109655; ENSXETG00000001136.
DR GeneID; 100124838; -.
DR KEGG; xtr:100124838; -.
DR AGR; Xenbase:XB-GENE-5818915; -.
DR CTD; 8131; -.
DR Xenbase; XB-GENE-5818915; nprl3.
DR eggNOG; KOG3830; Eukaryota.
DR HOGENOM; CLU_014030_1_0_1; -.
DR OrthoDB; 8983at2759; -.
DR TreeFam; TF105965; -.
DR Proteomes; UP000008143; Chromosome 9.
DR Bgee; ENSXETG00000001136; Expressed in skeletal muscle tissue and 13 other cell types or tissues.
DR GO; GO:1990130; C:GATOR1 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IEA:UniProtKB-UniRule.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR005365; Npr3.
DR PANTHER; PTHR13153; CGTHBA PROTEIN -14 GENE PROTEIN; 1.
DR PANTHER; PTHR13153:SF5; GATOR COMPLEX PROTEIN NPRL3; 1.
DR Pfam; PF03666; NPR3; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 2: Evidence at transcript level;
KW Lysosome {ECO:0000256|RuleBase:RU368069};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Signal {ECO:0000256|RuleBase:RU368069}.
FT REGION 39..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 567 AA; 63319 MW; 8034798488CD0585 CRC64;
MGENTSPISV ILVSSGSRGN KLLFRYPFQR NHEPQLSKTI NPRSCYALPN TGDNSDDPDG
DSKFSDVILA TILATKSDMC GKKFELKIDN VRFVGHPTLL QHAQVSKTDP SPKREAPTMI
LFNVVFALRA NADPSVINCL HNLSRRIAIV LQHEERRCQY LTREAKLILA IQDEVTAMSE
TNGGPQSPFH HILPKCKLAR DLKEAYDSLC TTGVVRLHIN NWLEVSFCLP HKIHCVGTNF
IPPDAIEKSL KSIRPYHALL LLKDEKNLLN DLPLDCSPAL VRIIKSASAV KNLQQLAQDA
DLALLQVFQL AAHLVYWGKA IIIYPLCENN VYMLSPNANV GLYSSLAEQF SHQFPAHDLP
SVLSKFSLPV SLSELKNPLS PPGQEPHLIQ MVIWMLQHRL LIQIHTYVCL LVPPNEDVAS
TKDEDTPFAA RVGGRSLSTP NALSFGSPTS SDDMTLTSPS MDNSSAELLP GADSPVNKRA
TENLLASLSQ HEREAILSIP AAQNQEDLKM FARLLHYFRG RHHLEEIMYN ENMRRSQLLM
LFDKFRSVLV VTNHEDPVIS VFQSVFP
//