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Database: UniProt
Entry: A4IHU3_XENTR
LinkDB: A4IHU3_XENTR
Original site: A4IHU3_XENTR 
ID   A4IHU3_XENTR            Unreviewed;       459 AA.
AC   A4IHU3;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   16-OCT-2019, entry version 94.
DE   SubName: Full=Fli1 protein {ECO:0000313|EMBL:AAI35690.1};
GN   Name=fli1 {ECO:0000313|EMBL:AAI35690.1,
GN   ECO:0000313|Ensembl:ENSXETP00000049289,
GN   ECO:0000313|Xenbase:XB-GENE-5794048};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI35690.1};
RN   [1] {ECO:0000313|EMBL:AAI35690.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Whole embryo {ECO:0000313|EMBL:AAI35690.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000049289}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000049289};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
RA   Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
RA   Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
RA   Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
RA   Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
RA   Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
RA   Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
RA   Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
RA   Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [3] {ECO:0000313|Ensembl:ENSXETP00000049289}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594391}.
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DR   EMBL; AAMC01038347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01038348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01038349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01038350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC135689; AAI35690.1; -; mRNA.
DR   RefSeq; NP_001096189.1; NM_001102719.1.
DR   SMR; A4IHU3; -.
DR   STRING; 8364.ENSXETP00000049289; -.
DR   Ensembl; ENSXETT00000049289; ENSXETP00000049289; ENSXETG00000022780.
DR   GeneID; 100124738; -.
DR   KEGG; xtr:100124738; -.
DR   CTD; 2313; -.
DR   Xenbase; XB-GENE-5794048; fli1.
DR   eggNOG; KOG3806; Eukaryota.
DR   eggNOG; ENOG410Z0ZF; LUCA.
DR   GeneTree; ENSGT00940000158261; -.
DR   HOGENOM; HOG000290658; -.
DR   KO; K09436; -.
DR   OMA; GWGSNMN; -.
DR   OrthoDB; 1113327at2759; -.
DR   TreeFam; TF350537; -.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   Bgee; ENSXETG00000022780; Expressed in 12 organ(s), highest expression level in embryo.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd08541; SAM_PNT-FLI-1; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR035575; Fli-1.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR035573; SAM_PNT-FLI-1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849:SF161; PTHR11849:SF161; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008143};
KW   DNA-binding {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT   DOMAIN      117    203       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      288    368       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION      207    280       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    234    280       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   459 AA;  51950 MW;  5D3BF8E78C0E2AD8 CRC64;
     MHLKKLVEHR KEALSVVSDD QSLFDSAYGA SSHLSKVDMT ASANPDYGQP HKINSIPPQQ
     DWINQSMRVN IKREYEHMNG SRESPVDCSI SKCSKLIGGS ENNAVTYNSY MDEKNGPPPP
     NMTTNERRVI VPADPTLWSQ DHVRQWLEWA IKEYGLVEID CTLFQNIDGK ELCKMSKEDF
     LRSTSIYNTE VLLSHLNYLR DSSSSLGYNT QAHTDQSPRL TAKEDPSYEA VRRSGWGNSL
     SSPVTKSPPI GGSQNVNKSV DQQRSQPDPY QILGPTSSRL ANPGSGQIQL WQFLLELLSD
     SSNASCITWE GTNGEFKMTD PDEVARRWGE RKSKPNMNYD KLSRALRYYY DKNIMTKVHG
     KRYAYKFDFH GIAQALQPHP TDTSMYKYPS EFSYMPSYHS HQQKVNFVPS HPSSMPVTSS
     GFFGATSPYW NSPSANIYPN PNVPRHPNTH VQSHLGGFY
//
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