ID A4J3E6_DESRM Unreviewed; 634 AA.
AC A4J3E6;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Biotin carboxyl carrier protein of acetyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00017562};
GN OrderedLocusNames=Dred_1064 {ECO:0000313|EMBL:ABO49599.1};
OS Desulforamulus reducens (strain ATCC BAA-1160 / DSM 100696 / MI-1)
OS (Desulfotomaculum reducens).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptococcaceae;
OC Desulforamulus.
OX NCBI_TaxID=349161 {ECO:0000313|EMBL:ABO49599.1, ECO:0000313|Proteomes:UP000001556};
RN [1] {ECO:0000313|EMBL:ABO49599.1, ECO:0000313|Proteomes:UP000001556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MI-1 {ECO:0000313|EMBL:ABO49599.1,
RC ECO:0000313|Proteomes:UP000001556};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Sims D., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F.,
RA Land M., Hauser L., Kyrpides N., Kim E., Tebo B.M., Richardson P.;
RT "Complete sequence of Desulfotomaculum reducens MI-1.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
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DR EMBL; CP000612; ABO49599.1; -; Genomic_DNA.
DR RefSeq; WP_011877425.1; NC_009253.1.
DR AlphaFoldDB; A4J3E6; -.
DR STRING; 349161.Dred_1064; -.
DR KEGG; drm:Dred_1064; -.
DR eggNOG; COG0511; Bacteria.
DR eggNOG; COG5016; Bacteria.
DR HOGENOM; CLU_000395_4_3_9; -.
DR OrthoDB; 9807469at2; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000001556; Chromosome.
DR GO; GO:0009317; C:acetyl-CoA carboxylase complex; IEA:InterPro.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:InterPro.
DR GO; GO:0004736; F:pyruvate carboxylase activity; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06850; biotinyl_domain; 1.
DR CDD; cd07937; DRE_TIM_PC_TC_5S; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR001249; AcCoA_biotinCC.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR003379; Carboxylase_cons_dom.
DR InterPro; IPR000891; PYR_CT.
DR InterPro; IPR011053; Single_hybrid_motif.
DR NCBIfam; TIGR00531; BCCP; 1.
DR PANTHER; PTHR45266; OXALOACETATE DECARBOXYLASE ALPHA CHAIN; 1.
DR PANTHER; PTHR45266:SF3; OXALOACETATE DECARBOXYLASE ALPHA CHAIN; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR Pfam; PF02436; PYC_OADA; 1.
DR PRINTS; PR01071; ACOABIOTINCC.
DR SUPFAM; SSF51569; Aldolase; 1.
DR SUPFAM; SSF89000; post-HMGL domain-like; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 4: Predicted;
KW Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Reference proteome {ECO:0000313|Proteomes:UP000001556}.
FT DOMAIN 5..265
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
FT DOMAIN 556..632
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT REGION 442..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 634 AA; 70115 MW; A60525601AFC828E CRC64;
MSHHLKITDT TLRDAHQSLW ATRMATEDML PILEKLDQMG YHSLEVWGGA TFDVCLRFLN
EDPWERLRLI RKYVKNTPLQ MLLRGQSLLG YMHYPDDVLE AFIHKTVENG MDIIRIFDAL
NDIRNMEKAI QATKAAGAHA QATVVYTVSP VHTTEHYLET ALRLEEMGAD SICIKDMAGL
LAPFKSYELV KLFKAHLQVP VQLHCHYIGG MAVGAYLKAA EAGVDVVDTA SVPMAFGASQ
PPVETVVRAL KGTPYDTGLS MKALFEVAQY FEDIRKVLGQ QRGVTRISDM RVFEHQVPGG
MISNLVSQLE EQKALHRLDE VLEEIPRVRE ELGFPPLVTP TSQIVGTQAV LNVLTGQRYK
LIPGEVKLYV EGYYGQPPAT IDPSVSRKVL GDKEAISCRP ADLLEPKLDK LRDEIKDLAI
SQEDILSYAM FPQVARKFFE ARKRGETGPQ RKEASIKPGA PADFSGTKST KEAKNVNLSE
LKELIKVLDQ TDITEIDLES DGVKVSIRKG GKVSATVTPA APQKTAETPV TEAPKTGEAS
VAPEVPVVST QPTEDLIPVT APMVGTFYRA PSPDADPFVN VGDIVEKGQT LCIVEAMKLM
NEIEAEQAGE IVQIMVENGQ PIEYGQNLFM IRKK
//
