ID A4JJ68_BURVG Unreviewed; 379 AA.
AC A4JJ68;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN OrderedLocusNames=Bcep1808_3332 {ECO:0000313|EMBL:ABO56321.1};
OS Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia
OS (strain R1808)).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=269482 {ECO:0000313|EMBL:ABO56321.1, ECO:0000313|Proteomes:UP000002287};
RN [1] {ECO:0000313|Proteomes:UP000002287}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G4 / LMG 22486 {ECO:0000313|Proteomes:UP000002287};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Tiedje J., Richardson P.;
RT "Complete sequence of chromosome 2 of Burkholderia vietnamiensis G4.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000615; ABO56321.1; -; Genomic_DNA.
DR AlphaFoldDB; A4JJ68; -.
DR KEGG; bvi:Bcep1808_3332; -.
DR eggNOG; COG1024; Bacteria.
DR HOGENOM; CLU_009834_22_1_4; -.
DR Proteomes; UP000002287; Chromosome 2.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Isomerase {ECO:0000313|EMBL:ABO56321.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002287}.
FT DOMAIN 27..362
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 379 AA; 42010 MW; D59011FAF2E042DF CRC64;
MSTPMTTDDR FAQPAPEVLF RVVNRVALIT LNRPAALNAL SYSMIGELAA LLERCRGDDQ
IVAVVLRGAG EKGFCAGGDV RALHRMVAQR ETWLPFFVDE YRLDYAIHTF PKPVVALMDG
VTMGGGMGLA QGAALRVATE RSKIAMPETR IGLVPDVGAT HFLSRMPVEL ELYVGLTGAV
LSGADALIAK LADLCVPSSW LDTFETRIES VKWDGDVLAA LRKVFEPPCN VVPHAALDTQ
MGWIVRHFDK RSTVERIVAT LKQEFARDEL AREHRQWLQT TLDALAGHSP TMLCVTREAL
LRGRQMTLAE SFRMELGIVA RAIEEGDFRE GVRAHLIDKD RKPRWAPASL VELRAERVRH
FLTSPWKLFA HPLVDLGGV
//
