ID UBL4A_XENTR Reviewed; 148 AA.
AC A4QND0;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Ubiquitin-like protein 4A;
GN Name=ubl4a;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: As part of a cytosolic protein quality control complex, the
CC bag6/bat3 complex, maintains misfolded and hydrophobic patches-
CC containing proteins in a soluble state and participates in their proper
CC delivery to the endoplasmic reticulum or alternatively can promote
CC their sorting to the proteasome where they undergo degradation. The
CC bag6/bat3 complex is involved in the post-translational delivery of
CC tail-anchored/type II transmembrane proteins to the endoplasmic
CC reticulum membrane. Similarly, the bag6/bat3 complex also functions as
CC a sorting platform for proteins of the secretory pathway that are
CC mislocalized to the cytosol either delivering them to the proteasome
CC for degradation or to the endoplasmic reticulum. The bag6/bat3 complex
CC also plays a role in the endoplasmic reticulum-associated degradation
CC (ERAD), a quality control mechanism that eliminates unwanted proteins
CC of the endoplasmic reticulum through their retrotranslocation to the
CC cytosol and their targeting to the proteasome. It maintains these
CC retrotranslocated proteins in an unfolded yet soluble state condition
CC in the cytosol to ensure their proper delivery to the proteasome.
CC {ECO:0000250|UniProtKB:P11441}.
CC -!- SUBUNIT: Component of the bag6/bat3 complex.
CC {ECO:0000250|UniProtKB:P11441}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:P11441}. Nucleus {ECO:0000250|UniProtKB:P11441}.
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DR EMBL; BC135438; AAI35439.1; -; mRNA.
DR RefSeq; NP_001096510.1; NM_001103040.1.
DR AlphaFoldDB; A4QND0; -.
DR SMR; A4QND0; -.
DR STRING; 8364.ENSXETP00000027400; -.
DR PaxDb; 8364-ENSXETP00000015581; -.
DR Ensembl; ENSXETT00000109391; ENSXETP00000116135; ENSXETG00000044549.
DR GeneID; 100125140; -.
DR KEGG; xtr:100125140; -.
DR AGR; Xenbase:XB-GENE-6455973; -.
DR CTD; 8266; -.
DR Xenbase; XB-GENE-6455973; ubl4a.
DR eggNOG; KOG0001; Eukaryota.
DR HOGENOM; CLU_119809_0_0_1; -.
DR InParanoid; A4QND0; -.
DR OMA; SMDTSYM; -.
DR OrthoDB; 2995082at2759; -.
DR PhylomeDB; A4QND0; -.
DR TreeFam; TF354228; -.
DR Proteomes; UP000008143; Chromosome 8.
DR GO; GO:0071818; C:BAT3 complex; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0071816; P:tail-anchored membrane protein insertion into ER membrane; ISS:UniProtKB.
DR CDD; cd01807; Ubl_UBL4A_like; 1.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR019954; Ubiquitin_CS.
DR InterPro; IPR019956; Ubiquitin_dom.
DR InterPro; IPR041421; Ubl4_C_TUGS.
DR InterPro; IPR044724; Ubl_UBL4A-like.
DR PANTHER; PTHR46555; UBIQUITIN-LIKE PROTEIN 4A; 1.
DR PANTHER; PTHR46555:SF1; UBIQUITIN-LIKE PROTEIN 4A; 1.
DR Pfam; PF17840; Tugs; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR PRINTS; PR00348; UBIQUITIN.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00299; UBIQUITIN_1; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome; Transport.
FT CHAIN 1..148
FT /note="Ubiquitin-like protein 4A"
FT /id="PRO_0000403749"
FT DOMAIN 1..76
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
SQ SEQUENCE 148 AA; 16552 MW; 18179EFB189DDE06 CRC64;
MQLTVKALKG KEANIQVSEG DTVLAVKRLV EEKLKVPVSQ QRLLFRGKAL ADEHCLAHYS
IGPGSRLNLM VKEQVAPEGH SGGNTAWKSL SVILRKHFSP TDAERVLEYV QKDYERSLSL
LSLDDIERLA TRILHPQYSE ATDLGFLD
//
