GenomeNet

Database: UniProt
Entry: A4RGD1
LinkDB: A4RGD1
Original site: A4RGD1 
ID   RRP3_MAGO7              Reviewed;         538 AA.
AC   A4RGD1; G4NEI8;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   16-OCT-2019, entry version 79.
DE   RecName: Full=ATP-dependent rRNA helicase RRP3 {ECO:0000305};
DE            EC=3.6.4.13 {ECO:0000250|UniProtKB:P38712};
GN   Name=RRP3 {ECO:0000250|UniProtKB:P38712}; ORFNames=MGG_17539;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice
OS   blast fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Magnaporthales; Pyriculariaceae;
OC   Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W.,
RA   Harding M., Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J.,
RA   Calvo S.E., Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E.,
RA   Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- FUNCTION: ATP-dependent rRNA helicase required for pre-ribosomal
CC       RNA processing. Involved in the maturation of the 35S-pre-rRNA and
CC       to its cleavage to mature 18S rRNA.
CC       {ECO:0000250|UniProtKB:P38712}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000250|UniProtKB:P38712};
CC   -!- SUBUNIT: Interacts with the SSU processome.
CC       {ECO:0000250|UniProtKB:P38712}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX47/RRP3
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EHA49465.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
DR   EMBL; CM001235; EHA49465.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_003719049.1; XM_003719001.1.
DR   SMR; A4RGD1; -.
DR   STRING; 318829.MGG_17539T0; -.
DR   PRIDE; A4RGD1; -.
DR   GeneID; 12985134; -.
DR   KEGG; mgr:MGG_17539; -.
DR   EuPathDB; FungiDB:MGG_17539; -.
DR   InParanoid; A4RGD1; -.
DR   KO; K14777; -.
DR   OrthoDB; 744428at2759; -.
DR   Proteomes; UP000009058; Chromosome 5.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    538       ATP-dependent rRNA helicase RRP3.
FT                                /FTId=PRO_0000294652.
FT   DOMAIN      141    312       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      336    486       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     154    161       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       110    138       Q motif. {ECO:0000305}.
FT   MOTIF       260    263       DEAD box. {ECO:0000305}.
FT   COMPBIAS     56     85       Asp-rich. {ECO:0000255}.
SQ   SEQUENCE   538 AA;  59474 MW;  1EBF5BFFD0D46C64 CRC64;
     MSSAKRVKLS HSKAPGPFRK PSSGDRAAAK VLTKKITQAP KAAAPIKQKA REAEEDDDDD
     DKDDKDEEDE EQNDDSSDEA SENDDSTPTV EEATKEGQTE LPSKEETPTK SFRDLGIVEP
     LCEACEALKF KKPTPIQEQA IPLALQGRDV IGIAETGSGK TAAFALPILQ SLLEKPQPLF
     GLVLAPTREL AAQIGQTFEA LGASISLRCA VVVGGLDMVS QSTALGKKPH IVVATPGRLL
     DHLEKTKGFS LRSLKFLVMD EADRLLDLDF GPILDKILKF LPRERRTFLF SATMSSKVES
     LQRASLRDPL KVSVSSSQEK TVSTLIQNPL FIPHKHKDVY LIYLANEFAG KTTIVFTRTV
     NEAQRVSILL RTLSFGAIPL HGQLSQSMRL GALNKFKARS RDILVATDVA ARGLDIPEVD
     LVINFDMPQD SMTYIHRVGR TARAGRSGRA ISIITQYDLE LWLRIEKAAL NGRKLPLFQP
     DKEEVMVFKE RVEEAQRHAR EEMKALHEDR GKKGAVLKGR KRGSATKRRH DDMDAEEG
//
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