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Database: UniProt
Entry: A4RMV8
LinkDB: A4RMV8
Original site: A4RMV8 
ID   ROK1_MAGO7              Reviewed;         775 AA.
AC   A4RMV8; G4MSF5;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   16-OCT-2019, entry version 78.
DE   RecName: Full=ATP-dependent RNA helicase ROK1;
DE            EC=3.6.4.13;
GN   Name=ROK1; ORFNames=MGG_04523;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice
OS   blast fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Magnaporthales; Pyriculariaceae;
OC   Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W.,
RA   Harding M., Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J.,
RA   Calvo S.E., Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E.,
RA   Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- FUNCTION: ATP-dependent RNA helicase involved in 40S ribosomal
CC       subunit biogenesis. Required for the processing and cleavage of
CC       35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Interacts with the U3 snoRNA and is associated with the
CC       90S and 40S pre-ribosomes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX52/ROK1
CC       subfamily. {ECO:0000305}.
DR   EMBL; CM001232; EHA53767.1; -; Genomic_DNA.
DR   RefSeq; XP_003713574.1; XM_003713526.1.
DR   STRING; 318829.MGG_04523T0; -.
DR   PRIDE; A4RMV8; -.
DR   EnsemblFungi; MGG_04523T0; MGG_04523T0; MGG_04523.
DR   GeneID; 2678041; -.
DR   KEGG; mgr:MGG_04523; -.
DR   EuPathDB; FungiDB:MGG_04523; -.
DR   InParanoid; A4RMV8; -.
DR   KO; K14779; -.
DR   OMA; HKIKVTD; -.
DR   OrthoDB; 400908at2759; -.
DR   Proteomes; UP000009058; Chromosome 2.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    775       ATP-dependent RNA helicase ROK1.
FT                                /FTId=PRO_0000294663.
FT   DOMAIN      254    485       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      533    698       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     267    274       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       191    219       Q motif. {ECO:0000250}.
FT   MOTIF       432    435       DEAD box.
FT   COMPBIAS     97    164       Lys-rich.
SQ   SEQUENCE   775 AA;  83748 MW;  7F6B5669768B24C9 CRC64;
     MDILKVLSRG TKQAPKKPGV PAATLAQANI PSAGVETNPQ LYHDNVGPPP KGKKRKRKSR
     TQDHDQADDA VDDDVELSDF DFFAPKTRRD SDGAGSKTKA ADVKKAKKDA DEADKARPIE
     LDECKRILRS HRLKYTLLPV QKAAPAKVEK SSAKKKKKKD KGDKVDGAAQ AAQGKSDKLP
     VFPQPLVSFS QLRSAYRISP RLADNLAKGS YKVPTEVQLG ALPLLLQPGF ALSHEGDGVD
     DDGKGGDGEA LAMLQGASAG VDFLAIAPTG SGKTLSFLLP AINGVLKRRA EKGETGGDSS
     NDTKHALEAI VVAPTRELAS QIANEGRKLA MGTGVRVVLM RKGMRVAAEE DSTEKKSEDQ
     EEDVFESEDE DSLSEDDEER EKSEKPSKKP NKAPITKADI LVTTPMLLLN FLSKGTSTTK
     KRLPRVRSLI LDEADVLLDQ LFREQTMGIW SACRNPNLRV SFWSATMASN IETHILDNLR
     AQADDAPAPP LIRLVVGLKD TAVPNISHRL VYTATESGKL LALRQLLHPA SFSTTTSSTT
     TPEDETPLRP PFLVFVQTIE RATALHEELK YDIPAAAGGA SRVAVLHSSM PESARAAVIR
     RFRAADVWVL ITTDVLARGV DFAGVNGVVN YDVPGSAAAY VHRAGRTGRA GRKGGIAVTF
     YTKEDIPFVK NVANVIALSE RQAGAGESAT QKWLLDALPD VSKKDKKELR EKGVESRRSV
     AASKGKARIT SKSAWERRKE NNRKGAIEGS KRRKIAARDQ GDGSDDGGEW GGIDD
//
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