ID A4RU70_OSTLU Unreviewed; 654 AA.
AC A4RU70;
DT 15-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 15-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE RecName: Full=phosphatidylinositol 3-kinase {ECO:0000256|ARBA:ARBA00012073};
DE EC=2.7.1.137 {ECO:0000256|ARBA:ARBA00012073};
GN ORFNames=OSTLU_34142 {ECO:0000313|EMBL:ABO95200.1};
OS Ostreococcus lucimarinus (strain CCE9901).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Bathycoccaceae; Ostreococcus.
OX NCBI_TaxID=436017 {ECO:0000313|EMBL:ABO95200.1, ECO:0000313|Proteomes:UP000001568};
RN [1] {ECO:0000313|EMBL:ABO95200.1, ECO:0000313|Proteomes:UP000001568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCE9901 {ECO:0000313|EMBL:ABO95200.1,
RC ECO:0000313|Proteomes:UP000001568};
RX PubMed=17460045; DOI=10.1073/pnas.0611046104;
RA Palenik B., Grimwood J., Aerts A., Rouze P., Salamov A., Putnam N.,
RA Dupont C., Jorgensen R., Derelle E., Rombauts S., Zhou K., Otillar R.,
RA Merchant S.S., Podell S., Gaasterland T., Napoli C., Gendler K.,
RA Manuell A., Tai V., Vallon O., Piganeau G., Jancek S., Heijde M.,
RA Jabbari K., Bowler C., Lohr M., Robbens S., Werner G., Dubchak I.,
RA Pazour G.J., Ren Q., Paulsen I., Delwiche C., Schmutz J., Rokhsar D.,
RA Van de Peer Y., Moreau H., Grigoriev I.V.;
RT "The tiny eukaryote Ostreococcus provides genomic insights into the paradox
RT of plankton speciation.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:7705-7710(2007).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|PIRNR:PIRNR000587}.
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DR EMBL; CP000583; ABO95200.1; -; Genomic_DNA.
DR RefSeq; XP_001416907.1; XM_001416870.1.
DR AlphaFoldDB; A4RU70; -.
DR SMR; A4RU70; -.
DR STRING; 436017.A4RU70; -.
DR EnsemblPlants; ABO95200; ABO95200; OSTLU_34142.
DR GeneID; 5001041; -.
DR Gramene; ABO95200; ABO95200; OSTLU_34142.
DR KEGG; olu:OSTLU_34142; -.
DR eggNOG; KOG0906; Eukaryota.
DR HOGENOM; CLU_004869_2_0_1; -.
DR OMA; LHKFAQY; -.
DR OrthoDB; 10350at2759; -.
DR Proteomes; UP000001568; Chromosome 3.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:EnsemblPlants.
DR GO; GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006897; P:endocytosis; IEA:EnsemblPlants.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:1900426; P:positive regulation of defense response to bacterium; IEA:EnsemblPlants.
DR GO; GO:0072593; P:reactive oxygen species metabolic process; IEA:EnsemblPlants.
DR GO; GO:2000214; P:regulation of proline metabolic process; IEA:EnsemblPlants.
DR GO; GO:0090333; P:regulation of stomatal closure; IEA:EnsemblPlants.
DR GO; GO:0009617; P:response to bacterium; IEA:EnsemblPlants.
DR GO; GO:0009751; P:response to salicylic acid; IEA:EnsemblPlants.
DR GO; GO:1902074; P:response to salt; IEA:EnsemblPlants.
DR GO; GO:0009651; P:response to salt stress; IEA:EnsemblPlants.
DR CDD; cd00896; PI3Kc_III; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR008290; PI3K_Vps34.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF7; PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR PIRSF; PIRSF000587; PI3K_Vps34; 2.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR000587};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000587};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000587};
KW Reference proteome {ECO:0000313|Proteomes:UP000001568};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000587}.
FT DOMAIN 120..297
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 373..639
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 654 AA; 74860 MW; 1E2DE40CC5420AB1 CRC64;
MEQQAELQQL ESFLVQYEQG TLPSVNWLDN LVFSRIRDAR SMQLRIAQAT DDFFQLLVEL
PVYVRPVIFR ERREDVEPLE IHSWQRLTWL VDDEVNLMLE NPAERKHQKL SRSVGRGVID
MELKPDGAEK RRLSAIIQLP PTRPLDMESQ NLLWKFRFAI SHDPRALTKF LKCVDWSDPA
ETQASVQLMR EWAPIGPAAA LELLTPTFSN SEVRRYAVSI LRQAENEDLL LYLLQLVQAL
RYETADDNEL AKFLVERAVA NEVVGNYLYW YVLVQRTPPP AERSMSAFRM FERASRAKDT
RGRSVWETLK FQRELMEKIT IITQEVNTLR GARKVERLRA ILSSDNTLGA VLTSFPQAIP
NPLNPTVLTT GILASESNVF KSALSPLKLA FQTLTGDSAT MIFKKGDDLR QDQLCVQMIS
LMDKLLKREN LDLKLTSYRV LATGNDTGLI EFVKSQGLAD ILKEHEKLTT YIALHNPDPH
GPNGCTMTSM MNFVKSCAGY SVITYLLGVG DRHLDNLMLA SDGRLFHIDF GFIMGRDPKI
SPPSMKLCKE MVEAMGEYFS EFKTYCCEAY NILRKSESVV LLLNLFSLMA DANIPDININ
QDYEKALLRF ESKFALELDD EAAMQHFISE IHRSSNAFLD PIFERAHRVA QYLR
//
