ID A4S2B4_OSTLU Unreviewed; 433 AA.
AC A4S2B4;
DT 15-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 15-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Cystathione gamma synthase {ECO:0000313|EMBL:ABO98015.1};
GN Name=CGS1 {ECO:0000313|EMBL:ABO98015.1};
GN ORFNames=OSTLU_33390 {ECO:0000313|EMBL:ABO98015.1};
OS Ostreococcus lucimarinus (strain CCE9901).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Bathycoccaceae; Ostreococcus.
OX NCBI_TaxID=436017 {ECO:0000313|EMBL:ABO98015.1, ECO:0000313|Proteomes:UP000001568};
RN [1] {ECO:0000313|EMBL:ABO98015.1, ECO:0000313|Proteomes:UP000001568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCE9901 {ECO:0000313|EMBL:ABO98015.1,
RC ECO:0000313|Proteomes:UP000001568};
RX PubMed=17460045; DOI=10.1073/pnas.0611046104;
RA Palenik B., Grimwood J., Aerts A., Rouze P., Salamov A., Putnam N.,
RA Dupont C., Jorgensen R., Derelle E., Rombauts S., Zhou K., Otillar R.,
RA Merchant S.S., Podell S., Gaasterland T., Napoli C., Gendler K.,
RA Manuell A., Tai V., Vallon O., Piganeau G., Jancek S., Heijde M.,
RA Jabbari K., Bowler C., Lohr M., Robbens S., Werner G., Dubchak I.,
RA Pazour G.J., Ren Q., Paulsen I., Delwiche C., Schmutz J., Rokhsar D.,
RA Van de Peer Y., Moreau H., Grigoriev I.V.;
RT "The tiny eukaryote Ostreococcus provides genomic insights into the paradox
RT of plankton speciation.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:7705-7710(2007).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|RuleBase:RU362118}.
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DR EMBL; CP000589; ABO98015.1; -; Genomic_DNA.
DR RefSeq; XP_001419722.1; XM_001419685.1.
DR AlphaFoldDB; A4S2B4; -.
DR STRING; 436017.A4S2B4; -.
DR EnsemblPlants; ABO98015; ABO98015; OSTLU_33390.
DR GeneID; 5003536; -.
DR Gramene; ABO98015; ABO98015; OSTLU_33390.
DR KEGG; olu:OSTLU_33390; -.
DR eggNOG; KOG0053; Eukaryota.
DR HOGENOM; CLU_018986_1_0_1; -.
DR OMA; NAFQIIQ; -.
DR OrthoDB; 6018at2759; -.
DR Proteomes; UP000001568; Chromosome 9.
DR GO; GO:0003962; F:cystathionine gamma-synthase activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR044639; CGS1/2.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR43379; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR PANTHER; PTHR43379:SF1; CYSTATHIONINE GAMMA-SYNTHASE 1, CHLOROPLASTIC-RELATED; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001568}.
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 249
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 433 AA; 47379 MW; C75AD714F8622DB4 CRC64;
MSAAMSAKAR TVVKLSATTR KSRGGTGRRG ATTRAANGEK PWGDSTQCVQ NGERKEGRPR
VSDSLTTPIV CTSTYHFKDT EELIAYQEGR YGSFEYGRYG NPTTKACEEK IRQLEGGEDA
LLSASGMCTA TTMLLALVPA GGHIVTTTDC YRRTRQFIQT FLPKMGITST VLDPSDYDGL
EKALKENKCS LYFSESPTNP YLRCVDIERI VNLCKPTGCL VCIDGTFATP CNSRALDFGA
DLVIHSASKF MGGHNDVLAG VIVGKKEAVA ACRQFHNILG GVIDPHAAYL VLRGLKTLSL
RVERHNDSAM RLAQYLEKHP KIDKVHYPGL PSHCDHEVAK KYMKGFGGVV SFEVKGDLWA
TAKFIDSCEL PYIAPSLGGV ESLIEQPTVV SYWDQGPEKR AEIGIKDNLV RFSTGIEDYV
DIEADIAQAL EKI
//
