ID A4S4F0_OSTLU Unreviewed; 1055 AA.
AC A4S4F0;
DT 15-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 15-MAY-2007, sequence version 1.
DT 13-SEP-2023, entry version 78.
DE RecName: Full=BRCA2 OB1 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=OSTLU_26389 {ECO:0000313|EMBL:ABO98718.1};
OS Ostreococcus lucimarinus (strain CCE9901).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Bathycoccaceae; Ostreococcus.
OX NCBI_TaxID=436017 {ECO:0000313|EMBL:ABO98718.1, ECO:0000313|Proteomes:UP000001568};
RN [1] {ECO:0000313|EMBL:ABO98718.1, ECO:0000313|Proteomes:UP000001568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCE9901 {ECO:0000313|EMBL:ABO98718.1,
RC ECO:0000313|Proteomes:UP000001568};
RX PubMed=17460045; DOI=10.1073/pnas.0611046104;
RA Palenik B., Grimwood J., Aerts A., Rouze P., Salamov A., Putnam N.,
RA Dupont C., Jorgensen R., Derelle E., Rombauts S., Zhou K., Otillar R.,
RA Merchant S.S., Podell S., Gaasterland T., Napoli C., Gendler K.,
RA Manuell A., Tai V., Vallon O., Piganeau G., Jancek S., Heijde M.,
RA Jabbari K., Bowler C., Lohr M., Robbens S., Werner G., Dubchak I.,
RA Pazour G.J., Ren Q., Paulsen I., Delwiche C., Schmutz J., Rokhsar D.,
RA Van de Peer Y., Moreau H., Grigoriev I.V.;
RT "The tiny eukaryote Ostreococcus provides genomic insights into the paradox
RT of plankton speciation.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:7705-7710(2007).
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DR EMBL; CP000591; ABO98718.1; -; Genomic_DNA.
DR RefSeq; XP_001420425.1; XM_001420388.1.
DR AlphaFoldDB; A4S4F0; -.
DR STRING; 436017.A4S4F0; -.
DR EnsemblPlants; ABO98718; ABO98718; OSTLU_26389.
DR GeneID; 5004323; -.
DR Gramene; ABO98718; ABO98718; OSTLU_26389.
DR KEGG; olu:OSTLU_26389; -.
DR eggNOG; KOG4751; Eukaryota.
DR HOGENOM; CLU_290257_0_0_1; -.
DR OMA; IASEMEW; -.
DR OrthoDB; 5484321at2759; -.
DR Proteomes; UP000001568; Chromosome 11.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR CDD; cd04493; BRCA2DBD_OB1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR015252; BRCA2_hlx.
DR InterPro; IPR036315; BRCA2_hlx_sf.
DR InterPro; IPR015187; BRCA2_OB_1.
DR InterPro; IPR002093; BRCA2_repeat.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF09169; BRCA-2_helical; 1.
DR Pfam; PF09103; BRCA-2_OB1; 1.
DR SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
DR PROSITE; PS50138; BRCA2_REPEAT; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000001568};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 394..469
FT /note="Breast cancer type 2 susceptibility protein helical"
FT /evidence="ECO:0000259|Pfam:PF09169"
FT DOMAIN 473..591
FT /note="BRCA2 OB1"
FT /evidence="ECO:0000259|Pfam:PF09103"
FT REGION 18..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 992..1055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1055 AA; 114919 MW; 1FC1639C42030D7C CRC64;
MPAPSPGVSV GALARCGNPF AHTPAWPKTQ RTTPETAAAA RRARGKGFMY LRDEDDDADA
VTPVSRRRAP ASAPGPSARA TAMAQSPFVI MQRHMAGSAT PYANLDAPAP DSVTLTTASG
KSVIARANGA IRTDEQPRFD DDDEAYEDAF TFRAAIETPA TTRAESGGVF TSAAPKGLVF
QTGGGASIAV SEDVKRRARA MFADVDENDP SSSGRERPSA AAATPPAASG GGGLVFQTAA
GATLELSEAA LKKSRAFLAE VGNENTPVRA AFPQPSFKTP KSLPAVRKAP SKAPGFTPPM
KSTTAFTPPM SILGARTAAS APRQAKRSRH DGTGASVGVA VHDLFAARVR MGMRAPLCTF
FNNLLPFQVR PAFVDTCVAT LNADTAKSLR LPSVERGLVG WREMRELMIK AGASDASLTN
EWVANAYKWI VWTQACMARA FPEKYAFGVL SESAVLQRML YKYEREINRA ERPHVRRILE
KDENPGAPAV YVVSAIRSMT TASGIGNVPT MSEIEISDGW YSVRARLDAK LTRAVREGRL
RVGYKIFVVG AELRGVTDAV SPLSDDAEMA YVCLHVNGAR LAPWDAALGR VTYNLTIPLR
SVVPDGGVVP RMLIHVRHAY PMMHQERRDA DKNVLRCEIA ERRAHAEWQR ARDSVLHELQ
DAMHNRIGGW GSEVDQERAI REALQEKNLY DRRTSAVLRL NVVGFMPSSK HESYRGPITR
GSTSAILTIW DADEALVDAA QPGQSFAVTA IKPRANAFIE GELSLSTTRY TRWTPIPQED
IAAQKLEHSE HEWRCLSVRA AVDLADLSRS GLVRKEFDAV ACTLHCGPPR STQRGRLSQW
IFCFDSSVLD STTPNAARPH LLAVEITGYD DDSFVKADDW MPSTKLFTEA RHECGPPLVL
RNLEFQHYDA DNGVYVARVP IENVSVTLAA QTPGIHRISV ASRDLERFCG SRDDRSRSII
ASLKSRARAL TGVPENAESL VDEMPWDEVH ASQEPASQYD PPRLSMDDDW NDENAQSLAD
EAVRLTRSAS KAPVVVPTPT PRRTPRRSSR GSASR
//
