ID A4S6Q2_OSTLU Unreviewed; 722 AA.
AC A4S6Q2;
DT 15-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 15-MAY-2007, sequence version 1.
DT 24-JAN-2024, entry version 95.
DE RecName: Full=DNA mismatch repair protein S5 domain-containing protein {ECO:0000259|SMART:SM01340};
GN ORFNames=OSTLU_51248 {ECO:0000313|EMBL:ABO99423.1};
OS Ostreococcus lucimarinus (strain CCE9901).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Bathycoccaceae; Ostreococcus.
OX NCBI_TaxID=436017 {ECO:0000313|EMBL:ABO99423.1, ECO:0000313|Proteomes:UP000001568};
RN [1] {ECO:0000313|EMBL:ABO99423.1, ECO:0000313|Proteomes:UP000001568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCE9901 {ECO:0000313|EMBL:ABO99423.1,
RC ECO:0000313|Proteomes:UP000001568};
RX PubMed=17460045; DOI=10.1073/pnas.0611046104;
RA Palenik B., Grimwood J., Aerts A., Rouze P., Salamov A., Putnam N.,
RA Dupont C., Jorgensen R., Derelle E., Rombauts S., Zhou K., Otillar R.,
RA Merchant S.S., Podell S., Gaasterland T., Napoli C., Gendler K.,
RA Manuell A., Tai V., Vallon O., Piganeau G., Jancek S., Heijde M.,
RA Jabbari K., Bowler C., Lohr M., Robbens S., Werner G., Dubchak I.,
RA Pazour G.J., Ren Q., Paulsen I., Delwiche C., Schmutz J., Rokhsar D.,
RA Van de Peer Y., Moreau H., Grigoriev I.V.;
RT "The tiny eukaryote Ostreococcus provides genomic insights into the paradox
RT of plankton speciation.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:7705-7710(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; CP000593; ABO99423.1; -; Genomic_DNA.
DR RefSeq; XP_001421130.1; XM_001421093.1.
DR AlphaFoldDB; A4S6Q2; -.
DR STRING; 436017.A4S6Q2; -.
DR EnsemblPlants; ABO99423; ABO99423; OSTLU_51248.
DR GeneID; 5004986; -.
DR Gramene; ABO99423; ABO99423; OSTLU_51248.
DR KEGG; olu:OSTLU_51248; -.
DR eggNOG; KOG1979; Eukaryota.
DR HOGENOM; CLU_004131_2_0_1; -.
DR OMA; ANYHVKK; -.
DR OrthoDB; 5475669at2759; -.
DR Proteomes; UP000001568; Chromosome 13.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblPlants.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR GO; GO:0006312; P:mitotic recombination; IEA:EnsemblPlants.
DR GO; GO:0009845; P:seed germination; IEA:EnsemblPlants.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001568}.
FT DOMAIN 226..351
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 370..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..394
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 722 AA; 80386 MW; 176F5F81E91D59F4 CRC64;
MTRGDGARDG ASTPRAIGRL PSDVVNRVAA GEVIHRPSNA LKELVENSLD AGAKSIAVTT
REGGNKLLRV QDDGHGVRIE DLPLLCERHA TSKIEKFEDL ARCESFGFRG EALASMSYVA
HVSATTMAAG ATHATRATYT DGKMDAEGAK PIAGVLGTTI SVENLFYNVV TRRKALKSAS
EEYSKVLEVL QRYAALRTDV AFTCRKHGES RATLHTPVAQ SRVERLQAIY GPTVARDLKK
LDFDSELSKK KFDFKLQVDG LVSGGNYHSK KTTFILFINS RLVECAPLKR ACESVYAAIL
PKAEKPFVFM HLRLPFEDVD VNVHPTKQEV HFLHQEAIVE LIQSKLEKIL LATNSSRTFT
VQTLLPGAEK LAKKDDENDA ERSGDKENSE KADEPPASQA KTMRTQRERA GGDHKLVRTD
ANLAAGSLDA YLQRAMNSEG REHEKIEEVR RAVRERRGQR TEPEDTYVCE LTSIRQLNTE
IANRAHKELG DVIKNHTLVG AVDARKGVWL LQHQTKLFMV DAVKLTEEMF HQMALKNFAN
FGYQSLQDPA SLAELALCAL EDKFVDDEEW DASDGSKEEV AEKIAEMLVE KADMLKEYLG
VVIDKERRQI TGVPSMLPGY APEIGKLPEF VLALAEDVDW TSEKECFETC ARVIGAFFAM
DCSFHDPKAE EGDAESDARR VARLCVFPAM KRRLAPPRRF ADDGTVIQIA CLEQLYKIFE
RC
//
