ID A4SXN7_POLAQ Unreviewed; 506 AA.
AC A4SXN7;
DT 15-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 15-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=methylmalonate-semialdehyde dehydrogenase (CoA acylating) {ECO:0000256|ARBA:ARBA00013048};
DE EC=1.2.1.27 {ECO:0000256|ARBA:ARBA00013048};
GN OrderedLocusNames=Pnuc_1035 {ECO:0000313|EMBL:ABP34251.1};
OS Polynucleobacter asymbioticus (strain DSM 18221 / CIP 109841 /
OS QLW-P1DMWA-1) (Polynucleobacter necessarius subsp. asymbioticus).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Polynucleobacter.
OX NCBI_TaxID=312153 {ECO:0000313|EMBL:ABP34251.1, ECO:0000313|Proteomes:UP000000231};
RN [1] {ECO:0000313|EMBL:ABP34251.1, ECO:0000313|Proteomes:UP000000231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18221 / CIP 109841 / QLW-P1DMWA-1
RC {ECO:0000313|Proteomes:UP000000231};
RX PubMed=22675600; DOI=10.4056/sigs.2395367;
RA Meincke L., Copeland A., Lapidus A., Lucas S., Berry K.W., Del Rio T.G.,
RA Hammon N., Dalin E., Tice H., Pitluck S., Richardson P., Bruce D.,
RA Goodwin L., Han C., Tapia R., Detter J.C., Schmutz J., Brettin T.,
RA Larimer F., Land M., Hauser L., Kyrpides N.C., Ivanova N., Goker M.,
RA Woyke T., Wu Q.L., Pockl M., Hahn M.W., Klenk H.P.;
RT "Complete genome sequence of Polynucleobacter necessarius subsp.
RT asymbioticus type strain (QLW-P1DMWA-1(T)).";
RL Stand. Genomic Sci. 6:74-83(2012).
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DR EMBL; CP000655; ABP34251.1; -; Genomic_DNA.
DR RefSeq; WP_011902876.1; NC_009379.1.
DR AlphaFoldDB; A4SXN7; -.
DR GeneID; 31481409; -.
DR KEGG; pnu:Pnuc_1035; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_1_10_4; -.
DR Proteomes; UP000000231; Chromosome.
DR GO; GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity; IEA:UniProtKB-EC.
DR CDD; cd07085; ALDH_F6_MMSDH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR010061; MeMal-semiAld_DH.
DR NCBIfam; TIGR01722; MMSDH; 1.
DR PANTHER; PTHR43866; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43866:SF4; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ABP34251.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000231}.
FT DOMAIN 28..486
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
SQ SEQUENCE 506 AA; 54760 MW; B17928C817E4A241 CRC64;
MNAPQAYASK DDIGHYVGGS LITPKDGRFS DVYNPSKGTV ARRVALASKQ EVDAAVAVAQ
KAFETWSLTS PLRRSRILFK YLELLNANRD ELAAIITAEH GKVFTDAQGE VTRGIEIVEF
ATGIPELLKG DYTEQVSTDI DNWVMRQPLG VVAGITPFNF PVMVPMWMFP MAIACGNTFI
LKPSPTDPSA SLFMAKLLKE AGLPDGVFNV VQGDKEAVDA LIENPDVKAV SFVGSTPIAN
YIYERCAHFG KRSQALGGAK NHMVIMPDAD IEKSIDALIG AAYGSAGERC MAISVAVLVG
DVAEKIMPKL IERTKTLKVK NGMELDAEMG PIVTKAALER ITGYIDSGVA SGAKLLVDGR
GLKVPGHEDG FFIGGTLFDN VTPDMKIYLE EIFGPVLSCL RVANFTEALN LVNSCEFGNG
VACFTSDGNI AREFARRVQV GMVGINVPIP VPMAWHGFGG WKKSIFGDMH AYGKEGVRFY
TKQKSVMQRW PESIAKGAEF VMPTSK
//
