ID   A4T8U1_MYCGI            Unreviewed;      1163 AA.
AC   A4T8U1;
DT   15-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   15-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   SubName: Full=Nuclease (RecB family)-like protein {ECO:0000313|EMBL:ABP44701.1};
GN   OrderedLocusNames=Mflv_2223 {ECO:0000313|EMBL:ABP44701.1};
OS   Mycolicibacterium gilvum (strain PYR-GCK) (Mycobacterium gilvum (strain
OS   PYR-GCK)).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=350054 {ECO:0000313|EMBL:ABP44701.1};
RN   [1] {ECO:0000313|EMBL:ABP44701.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PYR-GCK {ECO:0000313|EMBL:ABP44701.1};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P.;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABP44701.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PYR-GCK {ECO:0000313|EMBL:ABP44701.1};
RX   PubMed=23469141;
RA   Badejo A.C., Badejo A.O., Shin K.H., Chai Y.G.;
RT   "A Gene Expression Study of the Activities of Aromatic Ring-Cleavage
RT   Dioxygenases in Mycobacterium gilvum PYR-GCK to Changes in Salinity and pH
RT   during Pyrene Degradation.";
RL   PLoS ONE 8:E58066-E58066(2013).
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DR   EMBL; CP000656; ABP44701.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4T8U1; -.
DR   STRING; 350054.Mflv_2223; -.
DR   KEGG; mgi:Mflv_2223; -.
DR   eggNOG; COG1112; Bacteria.
DR   eggNOG; COG2251; Bacteria.
DR   HOGENOM; CLU_008884_0_0_11; -.
DR   OrthoDB; 9757917at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd17934; DEXXQc_Upf1-like; 1.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR019993; RecB_nuclease_TM0106_put.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   InterPro; IPR038720; YprB_RNase_H-like_dom.
DR   NCBIfam; TIGR03491; TM0106 family RecB-like putative nuclease; 1.
DR   PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR43788:SF6; RECBCD ENZYME SUBUNIT RECD; 1.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF13604; AAA_30; 1.
DR   Pfam; PF13482; RNase_H_2; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          322..509
FT                   /note="YprB ribonuclease H-like"
FT                   /evidence="ECO:0000259|Pfam:PF13482"
FT   DOMAIN          939..1119
FT                   /note="DNA2/NAM7 helicase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13087"
SQ   SEQUENCE   1163 AA;  127413 MW;  095C58930787F374 CRC64;
     MFVATDAGVD RVIFSASDLA AAARCEYALL RSFDDRLGRG PAVSGDDELL ARTATLGDQH
     EKRHLDELAL ASDVTVIGRP AYTVAGLTDA AGQTLRAVER RAPVIYQAAM FDGRFAGFAD
     FLLLEEGPDG QRYRLRDTKL ARSVKVEALL QMAAYVETLT AAGVPVAPEI DLVLGDGTAV
     SYPVDELLPV YRPRRAALQQ LLEDHLAGGR AVEWEDEHVR ACFRCAECDT QVRARDDLLL
     VAGMRVSARA RLLDAGITTV HELAAHRGPV AELSSRTVTA LTAQARLQVA RRVVENGTEK
     PPYEIVDPQP LMVLPDADKG DLFFDFEGDP LWTTDGRDWG LEYLWGVLTP GDEFQPFWAH
     NRTEERQALQ DFLKFVRKRR NRYPGMHIYH YAAYEKSALL RLAGRYGVGE HEVDELLRDG
     VLVDLYPLVR KSIRVGTENY SIKSLEPLYM GNELRDGDVT TATASITEYA HYCELRDDGN
     AEEAASVLKA IEDYNHYDCR STRRLRDWLM NRAIECGVPP RGPVRPSPDT DRPRAEVDAV
     ERTLLKFAGD GIEARTPEQR AAAMMAAAKG FHKREDKPFW WGHFDRVNNP VEEWADDSDV
     FIADRHEIVE DWHTPPRARK PQRHVRLFGE IANGGLATDM YALYDPPTPE GLSDDPDRRG
     FASVSVADCD NPEAPTEVVI VERRPTGGDV YTQVPFALTP GAPISTALLQ NAVADTAALI
     AAGLPNLPAD ALTDIFLRRP PRTRSGNPLP RTGGTVADLT AALLDLDSSY LAVHGPPGTG
     KTYTSGKVIA ALLTEHQWKI GVVAQSHAVV ENLFGDIMRA GVDGARVGKK RHTVSTGWTE
     LGRDDYVDFL CQGGCVVGGT AWDFANATKF ERECLDLLVI EEAGQFSLAN TVAVARAARN
     LMLLGDPQQL PQVSQGTHPE PVDGSALGWL VDGHATLPPE RGYFLDQSFR MHPDVCRAVS
     RLSYDGRLLS YETVTAARRL DGVAPGVRTL PVSHLGNATE SPEEADAIVT EIRRLLGAAW
     TDAASTDTDA TRPLDQTDVL IVTPYNAQVV LLRRRLDAAG LTRVRAGTVD KFQGQQAPVV
     FVSMTASSID DVPRGISFLL NRNRLNVAVS RAKYLAVVVR SEHLTDYLPG TPDRLVELGA
     FLSLTSGTAG VPGSVACDDR HRS
//