ID A4WGX7_PYRAR Unreviewed; 199 AA.
AC A4WGX7;
DT 29-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=orotidine-5'-phosphate decarboxylase {ECO:0000256|ARBA:ARBA00012321};
DE EC=4.1.1.23 {ECO:0000256|ARBA:ARBA00012321};
GN OrderedLocusNames=Pars_0027 {ECO:0000313|EMBL:ABP49644.1};
OS Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6).
OC Archaea; Thermoproteota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC Pyrobaculum.
OX NCBI_TaxID=340102 {ECO:0000313|EMBL:ABP49644.1, ECO:0000313|Proteomes:UP000001567};
RN [1] {ECO:0000313|EMBL:ABP49644.1, ECO:0000313|Proteomes:UP000001567}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700994 / DSM 13514 / JCM 11321 / PZ6
RC {ECO:0000313|Proteomes:UP000001567};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Cozen A.E.,
RA Fitz-Gibbon S.T., House C.H., Saltikov C., Lowe T.M., Richardson P.;
RT "Complete sequence of Pyrobaculum arsenaticum DSM 13514.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC UMP from orotate: step 2/2. {ECO:0000256|ARBA:ARBA00004861}.
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DR EMBL; CP000660; ABP49644.1; -; Genomic_DNA.
DR AlphaFoldDB; A4WGX7; -.
DR STRING; 340102.Pars_0027; -.
DR KEGG; pas:Pars_0027; -.
DR HOGENOM; CLU_067069_2_0_2; -.
DR OrthoDB; 94124at2157; -.
DR PhylomeDB; A4WGX7; -.
DR UniPathway; UPA00070; UER00120.
DR Proteomes; UP000001567; Chromosome.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd04725; OMP_decarboxylase_like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR014732; OMPdecase.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR32119; OROTIDINE 5'-PHOSPHATE DECARBOXYLASE; 1.
DR PANTHER; PTHR32119:SF2; OROTIDINE 5'-PHOSPHATE DECARBOXYLASE; 1.
DR Pfam; PF00215; OMPdecase; 1.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 4: Predicted;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:ABP49644.1}.
FT DOMAIN 3..191
FT /note="Orotidine 5'-phosphate decarboxylase"
FT /evidence="ECO:0000259|SMART:SM00934"
SQ SEQUENCE 199 AA; 21845 MW; 527EABC5CDDAA4FE CRC64;
MLPVIAALDV GVLKALDLVK LLKDKVAGFK VGWDLVFEGG ISIISEISRY GNVIVDLKLA
DIPYIVNRVI DKVVEKGACC AILHGFLYPS LPKGDRVYVL AKMTAPTLYD EVWERLVEQV
RDVRGFVLPG NKPEVVAYVR KKVGCSYRII TPGIGAQGGR PGEALRAGAD FEIVGRYILE
KPDRVTEWAG LSSRCFNTP
//
