ID   A4X5U2_SALTO            Unreviewed;       340 AA.
AC   A4X5U2;
DT   29-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 97.
DE   SubName: Full=Adenosine deaminase {ECO:0000313|EMBL:ABP54242.1};
DE            EC=3.5.4.4 {ECO:0000313|EMBL:ABP54242.1};
GN   OrderedLocusNames=Strop_1779 {ECO:0000313|EMBL:ABP54242.1};
OS   Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / JCM 13857 / NBRC
OS   105044 / CNB-440).
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Salinispora.
OX   NCBI_TaxID=369723 {ECO:0000313|EMBL:ABP54242.1, ECO:0000313|Proteomes:UP000000235};
RN   [1] {ECO:0000313|Proteomes:UP000000235}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-916 / DSM 44818 / CNB-440
RC   {ECO:0000313|Proteomes:UP000000235};
RX   PubMed=17563368; DOI=10.1073/pnas.0700962104;
RA   Udwary D.W., Zeigler L., Asolkar R.N., Singan V., Lapidus A., Fenical W.,
RA   Jensen P.R., Moore B.S.;
RT   "Genome sequencing reveals complex secondary metabolome in the marine
RT   actinomycete Salinispora tropica.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:10376-10381(2007).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
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DR   EMBL; CP000667; ABP54242.1; -; Genomic_DNA.
DR   RefSeq; WP_011905673.1; NC_009380.1.
DR   AlphaFoldDB; A4X5U2; -.
DR   STRING; 369723.Strop_1779; -.
DR   KEGG; stp:Strop_1779; -.
DR   PATRIC; fig|369723.5.peg.1826; -.
DR   eggNOG; COG1816; Bacteria.
DR   HOGENOM; CLU_039228_7_0_11; -.
DR   Proteomes; UP000000235; Chromosome.
DR   GO; GO:0046936; F:2'-deoxyadenosine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01430; aden_deam; 1.
DR   PANTHER; PTHR43114; ADENINE DEAMINASE; 1.
DR   PANTHER; PTHR43114:SF6; ADENINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:ABP54242.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000235}.
FT   DOMAIN          12..334
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   340 AA;  36789 MW;  CB5786512433EEA6 CRC64;
     MTDLSTFVAG LPKAELHVHH VGSASPRIVA ELAARHEGRS PVPADPAALA DYFAFRDFAH
     FVEVYLSVVD LIRDQEDVWL LTHEVARELA RQQVRYAELT VTPYSHVHRG IPAPAFCEAI
     EDARKRAAAD FGIELRWCFD IPGEAGLPAA EETLRISLDE RPDGLISFGL GGPEIGVPRP
     QFKPYFDQAR AAGLRSAPHA GETTGAQTVW DALRDLGAER IGHGIAAVED PELLEFLAER
     QIALEVCPTS NVRTRAVPRI EEHPLPRLVG AGLLVTINSD DPPMFGTTLN DEYAVAARLL
     GLGPQGVVAL AHNAVSASFL DPASKQRIAG EIDAYLARAS
//