ID A4X8U7_SALTO Unreviewed; 436 AA.
AC A4X8U7;
DT 29-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Cobalamin synthesis CobW domain protein {ECO:0000313|EMBL:ABP55297.1};
GN OrderedLocusNames=Strop_2856 {ECO:0000313|EMBL:ABP55297.1};
OS Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / JCM 13857 / NBRC
OS 105044 / CNB-440).
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Salinispora.
OX NCBI_TaxID=369723 {ECO:0000313|EMBL:ABP55297.1, ECO:0000313|Proteomes:UP000000235};
RN [1] {ECO:0000313|Proteomes:UP000000235}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-916 / DSM 44818 / CNB-440
RC {ECO:0000313|Proteomes:UP000000235};
RX PubMed=17563368; DOI=10.1073/pnas.0700962104;
RA Udwary D.W., Zeigler L., Asolkar R.N., Singan V., Lapidus A., Fenical W.,
RA Jensen P.R., Moore B.S.;
RT "Genome sequencing reveals complex secondary metabolome in the marine
RT actinomycete Salinispora tropica.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:10376-10381(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC subfamily. {ECO:0000256|ARBA:ARBA00034320}.
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DR EMBL; CP000667; ABP55297.1; -; Genomic_DNA.
DR RefSeq; WP_012014076.1; NC_009380.1.
DR AlphaFoldDB; A4X8U7; -.
DR STRING; 369723.Strop_2856; -.
DR KEGG; stp:Strop_2856; -.
DR PATRIC; fig|369723.5.peg.2942; -.
DR eggNOG; COG0523; Bacteria.
DR HOGENOM; CLU_017452_2_0_11; -.
DR Proteomes; UP000000235; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR036627; CobW-likC_sf.
DR InterPro; IPR011629; CobW-like_C.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR43603; COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527; 1.
DR PANTHER; PTHR43603:SF1; COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527; 1.
DR Pfam; PF02492; cobW; 1.
DR Pfam; PF07683; CobW_C; 1.
DR SMART; SM00833; CobW_C; 1.
DR SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000000235}.
FT DOMAIN 274..390
FT /note="CobW C-terminal"
FT /evidence="ECO:0000259|SMART:SM00833"
SQ SEQUENCE 436 AA; 47654 MW; 690E964B8C9BFAA1 CRC64;
MSSSPQAPTH TVTADGADIR PSLTVLSGFW PAATFAAARA LLAADTSLLL IRHDLAGIQD
GVVRRVVRTG TGIVEDEQVV LRHGCISCTL REDVLPTLVR LTRTHPGRDL VLMLPEAVEP
EAVAAATAHC LVNGAPITDL IRVDSYVTVL DAEHLLDGLA STDDLIALGI QAADDDDRAL
ADVVVRQIEY ADTLVLWGQS RDGEFDTGRM SVLLQRMAPW ATHLRVDGDL VDAGMLTRQL
RHTHRHRPET PGILARGLQG YTLGAHEPEP DCGVVSAVFR ARRPFHPQRL HDVLEEVNAE
VIRSRGHLWL ASQADTVIAW EFAGGGLAMG SLGHWLVSLP EDRWDHVEDQ RRLAAALDWD
PYYGDRHQHL VFIGLDIDPV ELHRTLAGCL LTDAELADGE DTWRTYPDPF AGCFPLSVEE
LADTDTDTDT EGARSA
//
