ID A4XHQ4_CALS8 Unreviewed; 613 AA.
AC A4XHQ4;
DT 29-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) {ECO:0000313|EMBL:ABP66439.1};
GN OrderedLocusNames=Csac_0821 {ECO:0000313|EMBL:ABP66439.1};
OS Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T
OS 6331).
OC Bacteria; Bacillota; Clostridia; Caldicellulosiruptorales;
OC Caldicellulosiruptoraceae; Caldicellulosiruptor.
OX NCBI_TaxID=351627 {ECO:0000313|EMBL:ABP66439.1, ECO:0000313|Proteomes:UP000000256};
RN [1] {ECO:0000313|Proteomes:UP000000256}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43494 / DSM 8903 / Tp8T 6331
RC {ECO:0000313|Proteomes:UP000000256};
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Kiss H., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Lykidis A., van de Werken H.J.G., Verhaart M.R.A.,
RA VanFossen A.L., Lewis D.L., Nichols J.D., Goorissen H.P., van Niel E.W.J.,
RA Stams F.J.M., Willquist K.U., Ward D.E., van der Oost J., Kelly R.M.,
RA Kengen S.M.W., Richardson P.;
RT "Genome sequence of the thermophilic hydrogen-producing bacterium
RT Caldicellulosiruptor saccharolyticus DSM 8903.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABP66439.1, ECO:0000313|Proteomes:UP000000256}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43494 / DSM 8903 / Tp8T 6331
RC {ECO:0000313|Proteomes:UP000000256};
RX PubMed=18776029; DOI=10.1128/AEM.00968-08;
RA van de Werken H.J., Verhaart M.R., VanFossen A.L., Willquist K.,
RA Lewis D.L., Nichols J.D., Goorissen H.P., Mongodin E.F., Nelson K.E.,
RA van Niel E.W., Stams A.J., Ward D.E., de Vos W.M., van der Oost J.,
RA Kelly R.M., Kengen S.W.;
RT "Hydrogenomics of the extremely thermophilic bacterium Caldicellulosiruptor
RT saccharolyticus.";
RL Appl. Environ. Microbiol. 74:6720-6729(2008).
RN [3] {ECO:0007829|PDB:3MTK}
RP X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS) OF 185-355.
RA Kuzin A., Abashidze M., Seetharaman J., Sahdev S., Xiao R., Ciccosanti C.,
RA Wang D., Everett J.K., Nair R., Acton T.B., Rost B., Montelione G.T.,
RA Tong L., Hunt J.F.;
RT "Northeast Structural Genomics Consortium Target ClR27C.";
RL Submitted (APR-2010) to the PDB data bank.
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DR EMBL; CP000679; ABP66439.1; -; Genomic_DNA.
DR RefSeq; WP_011916387.1; NC_009437.1.
DR PDB; 3MTK; X-ray; 2.24 A; A/B=185-355.
DR PDBsum; 3MTK; -.
DR AlphaFoldDB; A4XHQ4; -.
DR SMR; A4XHQ4; -.
DR STRING; 351627.Csac_0821; -.
DR DNASU; 5086821; -.
DR KEGG; csc:Csac_0821; -.
DR eggNOG; COG5001; Bacteria.
DR HOGENOM; CLU_000445_70_50_9; -.
DR OrthoDB; 9813903at2; -.
DR Proteomes; UP000000256; Chromosome.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR PANTHER; PTHR33121:SF71; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50112; PAS; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3MTK};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204}.
FT DOMAIN 36..92
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 219..348
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 357..610
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 613 AA; 71545 MW; 80AD8FEB8B5292CB CRC64;
MSFGNEKGQD IIHRKEVEFF VKNLKDYFSN INKYVVILWD EEGIILEFKE NGGNLLGYTP
EQIEGKKWPD ILTDGKDKEQ TTEINKKLVN SKIVRYYINS IKDVNGTSKI FLWCNLKLEN
VQSDKKIFLS VGFNLDSIDN LKEKTDESKF ELDTLNEKKE NLEFKVTKDD LILKQKDDTI
RDYKSKLEFL AFYDELTGLP NKNSLIRWLN LKVSQMDCID TYLIFLEVRD LEKLNVTYGY
DLVDELIIHI SKRIKDIAGE GNKAFKIGFD RFAIICKSEN ISDFIERMLS QLLLPYNVNG
NLIRVNFNIG AAQIENSNEA AANLMRRCDL ALIKAKEEGL NEYVIFKPSI EIQTLKEGIL
ERELRNGIEL NEFIVFYQPF VKLENDKICG FEALLRWYYL KSVFVSPLEF IPVAEKYGLI
IDLGNMVLKQ SLKAGKILKK YYDDEFTISI NISPKQFIDK RFVKNTIEIL ENEKLQDIRL
RFEITEKVAI ENIDYTIRIM NEFKKYNVTF ALDDFGVEYS SLNYLRKLPI EAVKIDKSFV
QDINDHDTYF IVETIVKLCK KLNLKTVIEG VETQRQYQII KELGCDYAQG YFIAKPLPIN
ELINLVGKYK ILE
//
