ID A4Y917_SHEPC Unreviewed; 1094 AA.
AC A4Y917;
DT 29-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=Tricorn protease homolog {ECO:0000256|PIRNR:PIRNR036421};
DE EC=3.4.21.- {ECO:0000256|PIRNR:PIRNR036421};
DE Flags: Precursor;
GN OrderedLocusNames=Sputcn32_2731 {ECO:0000313|EMBL:ABP76450.1};
OS Shewanella putrefaciens (strain CN-32 / ATCC BAA-453).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=319224 {ECO:0000313|EMBL:ABP76450.1};
RN [1] {ECO:0000313|EMBL:ABP76450.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CN-32 {ECO:0000313|EMBL:ABP76450.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Romine M.F., Fredrickson J.,
RA Tiedje J., Richardson P.;
RT "Complete sequence of Shewanella putrefaciens CN-32.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Degrades oligopeptides. {ECO:0000256|PIRNR:PIRNR036421}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR036421}.
CC -!- SIMILARITY: Belongs to the peptidase S41B family.
CC {ECO:0000256|ARBA:ARBA00008524, ECO:0000256|PIRNR:PIRNR036421}.
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DR EMBL; CP000681; ABP76450.1; -; Genomic_DNA.
DR AlphaFoldDB; A4Y917; -.
DR STRING; 319224.Sputcn32_2731; -.
DR KEGG; spc:Sputcn32_2731; -.
DR eggNOG; COG0793; Bacteria.
DR eggNOG; COG4946; Bacteria.
DR HOGENOM; CLU_005503_0_0_6; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-UniRule.
DR CDD; cd07562; Peptidase_S41_TRI; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.750.44; -; 1.
DR Gene3D; 2.120.10.60; Tricorn protease N-terminal domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR005151; Tail-specific_protease.
DR InterPro; IPR028204; Tricorn_C1.
DR InterPro; IPR029414; Tricorn_PDZ.
DR InterPro; IPR012393; Tricorn_protease.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR43253; TRICORN PROTEASE HOMOLOG 2-RELATED; 1.
DR PANTHER; PTHR43253:SF1; TRICORN PROTEASE HOMOLOG 2-RELATED; 1.
DR Pfam; PF07676; PD40; 2.
DR Pfam; PF03572; Peptidase_S41; 1.
DR Pfam; PF14684; Tricorn_C1; 1.
DR Pfam; PF14685; Tricorn_PDZ; 1.
DR PIRSF; PIRSF036421; Tricorn_protease; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00245; TSPc; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF69304; Tricorn protease N-terminal domain; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR036421};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR036421};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PIRNR:PIRNR036421};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825,
KW ECO:0000256|PIRNR:PIRNR036421}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1094
FT /note="Tricorn protease homolog"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002677343"
FT DOMAIN 758..849
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT ACT_SITE 753
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
FT ACT_SITE 975
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
FT ACT_SITE 1033
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
FT SITE 976
FT /note="Transition state stabilizer; via amide nitrogen"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-3"
SQ SEQUENCE 1094 AA; 121131 MW; 8F9A1DD2A9431711 CRC64;
MKLRHSVACC MLALGTLTAF QTIAADAVSN QGYYRAPALH NQTLVFTAEG DLWTQTLGQK
AATRLTSLPA EELGATISAD GKWVAYVANY EGASEVYVIP ITGGVAKRVS FENSRVRVQG
WTAKGDILYS TDTGFGPANN WMLRSVDPQT LTTTDLPLAD AVEGVIDDRN EYVYFTRFGL
QVTGDNAKVY RGGAKGELWR FKLGSKTEAQ LLSGQHDGSV RQPMLWQDRL YFISDSDGND
NLWSSALDGS DAKQLTQFKD WQVRGARMDQ GKVVFQLGAD IHVFDIAAAK DSLLNIELTS
DFAERREHWV KDPMDYASST NLAPAGDKVV ITARSHVAIA GIDGSRLVQV ALPGTYRVRE
AVLSQDGKSV YAISDMTGQQ EIWQFPADGS SGAKQLTKDG HTLRMSLNLS SDGRFIAHDD
NDGNVWLLDL KKNTNQKIIT NGEGLGPYAD ICWSSDSRFI ALTKSEIGKQ RPQIVLYSVD
ENKAETLTSD KYESYSPTFS SDGQWLYFLS NRQFSATPSS PWGDRNMGPV FDKRSQIFAI
ALVKNAKFPF SKPNELESNQ VEKNDAKDKP SPVKIDWAGI SQRLWQVPVD SGNYSKLRVV
DDRLYLLDQA IGDDVAPNLM TIKFDRLSPK AEVFAEDIGQ YEVSADGKKL MLRKHSNDKS
LLIVDGGDKL GDTDNAKVQT EQWQLAISPQ LEWQQMFEDA WLMHRESFFD KKMRGLDWQA
TKAKYQPLLD RLTDRNELND IFMQMMGELD SLHSQVRGGD LPKDPDAAKA ASLGARLQQT
ADGVKIAHIY SNDPELPANA SPLNRIEVDA KAGDMLLAIN GTPVANVADV TRLLRNQQDK
QVLLQLKRGS QTHKTIVMPV SAMVDSQLRY LDWVSHNAAV VEDASQGKMG YLHLYAMGGG
DIESFAREFY ANYDKEGLII DVRRNRGGNI DSWIIEKLLR RAWAFWQPTH GTPNTNMQQT
FRGHLVVLTD ELTYSDGETF SAGIKALGIA PLIGKQTAGA GVWLSGRNAL TDKGMARVAE
YPQYAMDGRW VLEGHGVTPD IEVDNLPFAT FNGKDAQLEA AISYLKDELV KQPIPALKAQ
PMPVKGMAQD INAN
//
