ID A4YG33_METS5 Unreviewed; 699 AA.
AC A4YG33;
DT 29-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=AMP-dependent synthetase and ligase {ECO:0000313|EMBL:ABP95385.1};
GN OrderedLocusNames=Msed_1224 {ECO:0000313|EMBL:ABP95385.1};
OS Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509
OS / TH2).
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Metallosphaera.
OX NCBI_TaxID=399549 {ECO:0000313|EMBL:ABP95385.1, ECO:0000313|Proteomes:UP000000242};
RN [1] {ECO:0000313|EMBL:ABP95385.1, ECO:0000313|Proteomes:UP000000242}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2
RC {ECO:0000313|Proteomes:UP000000242};
RX PubMed=18083856; DOI=10.1128/AEM.02019-07;
RA Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.;
RT "The genome sequence of the metal-mobilizing, extremely thermoacidophilic
RT archaeon Metallosphaera sedula provides insights into bioleaching-
RT associated metabolism.";
RL Appl. Environ. Microbiol. 74:682-692(2008).
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DR EMBL; CP000682; ABP95385.1; -; Genomic_DNA.
DR AlphaFoldDB; A4YG33; -.
DR STRING; 399549.Msed_1224; -.
DR KEGG; mse:Msed_1224; -.
DR eggNOG; arCOG00856; Archaea.
DR eggNOG; arCOG03859; Archaea.
DR HOGENOM; CLU_000022_59_5_2; -.
DR Proteomes; UP000000242; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR CDD; cd00090; HTH_ARSR; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR011991; ArsR-like_HTH.
DR InterPro; IPR001845; HTH_ArsR_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43767; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR PANTHER; PTHR43767:SF11; MEDIUM-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF12840; HTH_20; 1.
DR SMART; SM00418; HTH_ARSR; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:ABP95385.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000242}.
FT DOMAIN 10..81
FT /note="HTH arsR-type"
FT /evidence="ECO:0000259|SMART:SM00418"
SQ SEQUENCE 699 AA; 78198 MW; 179305087F0AE334 CRC64;
MCKYSFGLMD IFEAISNETR RRIIQSLSTP KTFSELANEL GLDSPSLSFH LRKLGGLVTK
NGDGTYRLTD DGVKALNLLS TISSGDTRLF PIVVEHLNYV KIDDELLVKL RNEGRKLVVR
KVKNLDLSEV NSSLLNEVLE VIENVDNLSC SNDTLSLIKD RIKGKYNLLI ADQEKLPNET
KHENPSPESL LTSFLSYTIS KLPVLSNLHV VYDDQIPLSN TLEINLSGGL SNSRRTYTYE
DFARRVRKTV TFLKQNGLEG KNVASIAWNT SRHLELYFAV PLSGGVLHTV NVRFHPREMD
YVVEEMQDSA VFMDEDIEAS LNVKTFRLNE SYDEIIDSQE PAQELPDLEE KRGAVSCFTS
GTTGKPKGVI YSHRSIFIHS LSLLAGDVLG LSSNDVVMDV VPMFHISGWD IPFASLMTGA
KLVLPGIRPK PRDLVELIKE EGVTLAAGAP TVWIDVMNYV EKEREDLGKL RTVVMGGAEP
PKGLMERMRK LGVRTYHAWG MTETEAIATV NRSDDLNVLT KQGYPIFGFE ISLLDPAGRE
LPWDGKTMGE LAVRGAFVTG RYFKGEAKFT WFRTGDIAVV DPDGNVKVVD RQKDLIKSGG
EWISSVQLEN AIMSFHKVSE AVVVGVHDER WGERPVALVV PKEPTTPQEV VEYLKSLNAF
PNWWIPDRII FVDSIPKTST GKLDKKVVRE EVKKLLQSP
//
