ID A4YGM9_METS5 Unreviewed; 391 AA.
AC A4YGM9;
DT 29-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:ABP95581.1};
DE EC=1.1.1.35 {ECO:0000313|EMBL:ABP95581.1};
GN OrderedLocusNames=Msed_1423 {ECO:0000313|EMBL:ABP95581.1};
OS Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509
OS / TH2).
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Metallosphaera.
OX NCBI_TaxID=399549 {ECO:0000313|EMBL:ABP95581.1, ECO:0000313|Proteomes:UP000000242};
RN [1] {ECO:0000313|EMBL:ABP95581.1, ECO:0000313|Proteomes:UP000000242}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2
RC {ECO:0000313|Proteomes:UP000000242};
RX PubMed=18083856; DOI=10.1128/AEM.02019-07;
RA Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.;
RT "The genome sequence of the metal-mobilizing, extremely thermoacidophilic
RT archaeon Metallosphaera sedula provides insights into bioleaching-
RT associated metabolism.";
RL Appl. Environ. Microbiol. 74:682-692(2008).
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
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DR EMBL; CP000682; ABP95581.1; -; Genomic_DNA.
DR AlphaFoldDB; A4YGM9; -.
DR STRING; 399549.Msed_1423; -.
DR KEGG; mse:Msed_1423; -.
DR eggNOG; arCOG00249; Archaea.
DR HOGENOM; CLU_009834_2_0_2; -.
DR Proteomes; UP000000242; Chromosome.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000313|EMBL:ABP95581.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000242}.
FT DOMAIN 3..177
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 183..277
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 298..388
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 391 AA; 43633 MW; 742CB8293FACF2BD CRC64;
MRIAVVGSGT MGHGIAEVAA MAGMEVKLID ISWDILNRAK ERMYDSLKRL HERGTIRETP
DTVMSRIEIS VSYDVAKDVD FAIEAVPEIL ELKRKVFQEL DRVVPKESIL ATNTSSIPIS
DIGEITSRKE KVIGMHFFNP PPLMKLVEVI PSKYTSEDVT RYTVELAKKM GKTPVRLRVE
VPGFVSNRIF LRLLQEACRE VESGEATIEE VDSSARNKLK LPMGIFELAD YVGLDVAVDL
WKVIVERGAS DVKCSSYKER VDRKELGVKT GKGFYTYPAP GKYSKVSLPP ESKVPPERII
SLAVNEGAWL IENNIVNAEE IDTVMRLGFN FPKGLLEMAD ELGLDKILNA LREIHSRGYE
AYSPNPLLVK MVSQGQTGKS SGRGFYTYGK T
//
