ID MUTS_BRASO Reviewed; 916 AA.
AC A4YKQ0;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BRADO0537;
OS Bradyrhizobium sp. (strain ORS 278).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae; Bradyrhizobium.
OX NCBI_TaxID=114615;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ORS 278;
RX PubMed=17540897; DOI=10.1126/science.1139548;
RA Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C.,
RA Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L.,
RA Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z.,
RA Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.-S., Saunders E.,
RA Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G.,
RA Emerich D., Vermeglio A., Medigue C., Sadowsky M.;
RT "Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.";
RL Science 316:1307-1312(2007).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CU234118; CAL74476.1; -; Genomic_DNA.
DR AlphaFoldDB; A4YKQ0; -.
DR SMR; A4YKQ0; -.
DR STRING; 114615.BRADO0537; -.
DR KEGG; bra:BRADO0537; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_1_3_5; -.
DR Proteomes; UP000001994; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..916
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000335121"
FT BINDING 665..672
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 916 AA; 98788 MW; BEC7B725D4B5BF4A CRC64;
MASFRAMTIQ QPISVPVPQE ATPAEAPAKL TPMMEQYLDI KAAHPGLMLF YRMGDFYELF
FEDAEVASKA LGIVLTKRGK HQGQDIPMCG VPVERSEDYL HRLIAQGIRV AVCEQMEDPA
AARARGNKSV VKRGVVRVVT PGTLTEDNLL DARANNYLLS IARSRGSSGG DRLGLAWIDI
STSDFIVTEC AFAELTATLA RINPNEVIVS DALYSDEAFE PVLRELAAVT PLTRDVFDGA
TAERRLCDYF AVATMDGLAV LSRLEATAAA ACVTYVERTQ VGQRPPLAPP AREATGSTMA
IDPATRANLE LTRTLAGERR GSLLDAIDCT VTSAGSRLLA QRLAAPLTEP AQIGRRLDAV
NAFVADSAAR EDIRVILRGA PDMTRAMARL SVGRGGPRDL AALRDGILAA DQALARLSVL
DQPPQEIASV MAALARPARA LADEFARALD EQLPLIKRDG GFVRSGYDAT LDETRNLRDA
SRLVVASMQA RYADQTGVKA LKIRHNNVLG YFVEVTAQHG DKLMSAPLNA TFIHRQTLAG
QVRFTTSELG EIEAKIANAG ERALNLELEI FDRLCAQALA IGDDLRAAAH GFAMLDVATA
LAKLALDDNY VRPEVDGSLG FAIEGGRHPV VEQSLKREGQ PFIANSCDLS PTPGHKSGQL
WLLTGPNMAG KSTFLRQNAL IALLAQIGSF VPASRARIGI VDRLFSRVGA ADDLARGRST
FMVEMVETAA ILNQAGERAL VILDEIGRGT ATFDGLSIAW AAIEHLHESN RCRTLFATHY
HELTALAAKL PRLFNATVRV KEWQGDVVFL HEVLPGSADR SYGIQVAKLA GLPPAVISRA
KSVLAKLEAA DRGQNARALV DDLPLFAVPS RAAVEPAMSK ETEELIAAVK DLHPDEMTPR
EALDALYRLK AKLPAK
//
